Spectroscopic investigation on the binding of antineoplastic drug oxaliplatin to human serum albumin and molecular modeling

Y Yue, X Chen, J Qin, X Yao - Colloids and Surfaces B: Biointerfaces, 2009 - Elsevier
… In this paper, the reaction of HSA and oxaliplatin was investigated by spectroscopic method.
The fluorescence of HSA was quenched by oxaliplatin with static quenching mechanism. …

Structural aspects of the anti-cancer drug oxaliplatin: A combined theoretical and experimental study

P Tyagi, P Gahlot, R Kakkar - Polyhedron, 2008 - Elsevier
… antitumor drug, oxaliplatin, has been explored by GGA-PW91 density functional calculations
and FT-IR spectra. The difference in the biological activities of cisplatin and oxaliplatin are …

Binding of platinum derivative, oxaliplatin to deoxyribonucleic acid: structural insight into antitumor action

B Ray, B Gupta, R Mehrotra - Journal of Biomolecular Structure and …, 2019 - Taylor & Francis
… DACH) and exert its anticancer action by inhibiting DNA replication and transcription. The …
study highlights the binding properties of oxaliplatin with calf thymus DNA using spectroscopic

Raman and infrared studies of platinum-based drugs: cisplatin, carboplatin, oxaliplatin, nedaplatin, and heptaplatin

M Torres, S Khan, M Duplanty, HC Lozano… - The Journal of …, 2018 - ACS Publications
… This study reports the optimized structures and lowest-energy conformations/… 2 present
normal Raman spectra of the five anticancer drugs (cisplatin, carboplatin, oxaliplatin, nedaplatin, …

Exploring binding affinity of oxaliplatin and carboplatin, to nucleoprotein structure of chromatin: Spectroscopic study and histone proteins as a target

H Soori, A Rabbani-Chadegani, J Davoodi - European Journal of Medicinal …, 2015 - Elsevier
anticancer drugs is related to their interaction with biological targets. Platinum-based drugs
are among the most effective anticancer agents … a potent target for most anticancer drugs [26]. …

Probing of the interaction between β-lactoglobulin and the anticancer drug oxaliplatin

B Ghalandari, A Divsalar, M Eslami-Moghadam… - Applied biochemistry …, 2015 - Springer
… with oxaliplatin were studied using various spectroscopic … with a molecular docking study.
Fluorescence measurements … present study, we investigated the interactions of oxaliplatin (…

Study on the interactions between anti-cancer drug oxaliplatin and DNA by atomic force microscopy

L Li, R Liu, F Xu, Y Zu, Z Liu - Micron, 2015 - Elsevier
… of action of oxaliplatin is still controversial. In this study, the interactions between oxaliplatin
and a … , mass spectrometry, circular dichroism and terahertz spectroscopy have been used to …

Oxaliplatin effects on the DNA molecule studied by force spectroscopy

L Oliveira, JM Caquito Jr… - Biomedical Physics & …, 2019 - iopscience.iop.org
… In the present study we investigated the binding of the anticancer compound Oxaliplatin to
DNA. Using optical tweezers to perform single molecule force spectroscopy, we determined …

Characterizing Pt‐Derived Anticancer Drugs from First Principles: The Case of Oxaliplatin in Aqueous Solution

EC Beret, RR Pappalardo, D Marx… - …, 2009 - Wiley Online Library
… characterized it by means of EXAFS spectroscopy.11, 12 In their … In those investigations we
have thoroughly studied the … a computational study on the modern anticancer drug oxaliplatin

Theoretical insights into the formation, structure, and electronic properties of anticancer oxaliplatin drug and cucurbit[n]urils n = 5 to 8

A Suvitha, NS Venkataramanan, H Mizuseki… - Journal of Inclusion …, 2010 - Springer
… Geometries, formation and electronic properties of cucurbit[n]uril-oxaliplatin n = 5–8, host-guest
complexes are investigated with DFT calculations. The formation of inclusion complexes …