… effect of antineoplastic agents in MMR-deficient tumour cells. Acknowledgements Our own
contributions concerning the involvement of the MMR system in drug resistance cited in this …

… Rather than reviewing each antineoplastic drug and the known mechanisms by which resistance
to … detoxification enzymes) may play an important role in antineoplastic drug resistance. …

… We infer that the assay's high specificity for drug resistance can be primarily attributed to (a)
the high drug concentrations used, (b) avoidance of technical artifacts through …

… limits the efficacy of antitumor drugs. A major mechanism that … In addition, cancer cells
can become resistant to drugs via … antitumor efficacy, overcomes drug resistance in cancer. …

… develop multidrug resistance to natudproduct antineoplastic drugs due to … drug efflux pump
(classical multidrug resistance or MDR).8 Decreased activation of pro-drugs, enhanced drug …

… of cancer, summarized how the TME contributes to non-cell-autonomous drug resistance
in different types of antineoplastic treatment, and discussed the novel strategies to investigate …

… The quiescent status of these cells makes them less sensitive to the great majority of
antineoplastic drugs, among which are paclitaxel and topotecan [20]. However, hypoxia may exert a …

… may be less effective than a combined modality approach, which integrates radiation and
chemotherapy prior to the development of drug resistance and cross-resistance to irradiation. …

One mechanism by which drugs alter the function of enzymes is through chronic inhibition.
To determine whether commonly used cancer chemotherapeutic agents could alter protein …

… Resistance to antineoplastic drugs is a major impediment to further improvements in the
chemotherapy of brain tumors. The mechanisms of drug resistance are … to drug resistance. An …