… mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic …

J Mao, DD Price, DJ Mayer - Pain, 1995 - Elsevier
antinociceptive effects of morphine. In this study, we examined the hypothesis that reduction
of morphine antinociception … intrathecal treatment with 10 p~g morphine sulfate (30 min after …

The peripheral antinociceptive effect induced by morphine is associated with ATP‐sensitive K+ channels

ARA Rodrigues, IDG Duarte - British journal of pharmacology, 2000 - Wiley Online Library
Morphine at the dose of 100 μg, … an antinociceptive effect in the right paw, whereas morphine
at the dose of 200 μg when injected into the left paw induced a potent antinociceptive effect

Methadone maintenance patients are cross-tolerant to the antinociceptive effects of morphine

M Doverty, AA Somogyi, JM White, F Bochner… - Pain, 2001 - journals.lww.com
… the intensity and duration of the antinociceptive effects of morphine at two target controlled
… we set out to determine if the antinociceptive effects of morphine are affected by changes in …

Peripheral antinociceptive effects of N-methyl morphine

TW Smith, P Buchan, DN Parsons, S Wilkinson - Life Sciences, 1982 - Elsevier
… [hat the antinociceptive effects of morphine and N-methyl morphine were antagonized by …
of the effects of N-methyl morphine only, the antinociceptive pr :ency of morphine being …

The antinociceptive effect of the combination of spinal morphine with systemic morphine or buprenorphine

A Nemirovsky, L Chen, V Zelman… - Anesthesia & Analgesia, 2001 - journals.lww.com
… In the next series of experiments, we evaluated the antinociceptive effect of the combinations
of IT morphine and SC buprenorphine. The D 50 values for both drugs alone and in …

An Examination of the Interactions Between the Antinociceptive Effects of Morphine and Various [micro sign]-Opioids: The Role of Intrinsic Efficacy and Stimulus …

D Morgan, CD Cook, MA Smith… - Anesthesia & Analgesia, 1999 - journals.lww.com
… differently than lower efficacy opioids interact with morphine? … morphine and several
other drugs in an antinociceptive … ), and morphine's antinociceptive effects were examined in …

Etanercept restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in morphine-tolerant rats

CH Shen, RY Tsai, MS Shih, SL Lin, YH Tai… - Anesthesia & …, 2011 - journals.lww.com
… In the present study, the TNF-α biological antagonist etanercept preserved the antinociceptive
effect of morphine in morphine-tolerant rats. Etanercept effectively suppressed microglia …

Antinociceptive effects of morphine, fentanyl, tramadol and their combination, in morphine-tolerant mice

A Romero, HF Miranda, MM Puig - Pharmacology Biochemistry and …, 2010 - Elsevier
… Initially, we tested the antinociceptive effects induced by the sc administration of M (…
morphine-pellet respectively), FEN (0.02–0.07 mg/kg in placebo-pellet, or 0.2–0.7 mg/kg in morphine-…

Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat

SP Letrent, GM Pollack, KR Brouwer… - Drug metabolism and …, 1999 - ASPET
… Concentrations of unbound morphine-… morphine concentration profiles and concentration-effect
relationships. The results of this study indicate that alteration of morphine antinociception

Assessment of a von Frey device for evaluation of the antinociceptive effects of morphine and its application in pharmacodynamic modeling of morphine in dogs

B KuKanich, BDX Lascelles… - American journal of …, 2005 - Am Vet Med Assoc
morphine in dogs; therefore, M6G is unlikely to contribute to analgesic effects associated with
morphine … of plasma morphine or M6G concentrations with antinociceptive effects in dogs …