… sequence termed antioxidant response element (ARE)… Nrf2 and triggering its nuclear
translocation in response to oxidative stress. We show here that phosphorylation of purified rat Nrf2 …

… Nrf2 is phosphorylated in vivo by MAPKs. We have identified multiple serine/threonine residues
as major targets of MAPK-mediated phosphorylation. … transcriptional activity of Nrf2, most …

… in HepG2 cells appeared to require PKC as shown above, we asked whether the activation
in Nrf2 phosphorylation upon antioxidant treatment could be accounted for by an increase in …

… phosphorylation of Ser 40 is necessary for Nrf2 release from INrf2, but is not required for Nrf2
… A peptide that competes with endogenous Nrf2 for INrf2 binding was able to induce ARE …

… Nrf2 is a master regulator of the antioxidant response and … range of antioxidant and Phase
II detoxification genes [1], [2]. … the phosphorylation of critical Nrf2 residues directly affects Nrf2 …

… They elucidated that all four Src subfamily kinases (Src, Yes, Fyn and Fgr) but not Lyn
phosphorylate Nrf2 Tyr568 and lead to the nuclear export, ubiquitination and degradation of …

… Nrf2 to trigger the antioxidant response 26, 40. After Nrf2 translocates into the nucleus, Nrf2
… of these two phosphorylation sites can influence Nrf2 nuclear export mediated by NESzip. …

… Similarly, the protein phosphatase inhibitor okadaic acid also caused an accumulation of
Nrf2… that Nrf2 is degraded by the ubiquitin-dependent pathway and that phosphorylation of Nrf2 …

… siRNA or increasing eIF2α phosphorylation with salubrinal did not affect Nrf2 elevation by H
… onset of the antioxidant/detoxification response via increased translation of Nrf2 by oxidants. …

… and GSK-3β inhibits the antioxidant response elements of the ho1 promoter and pointed
Nrf2 as directly involved in this process. Indeed, GSK-3β phosphorylated Nrf2 in vitro and in vivo…