Antiplatelet drug'resistance'. Part 1: mechanisms and clinical measurements

JM Sweeny, DA Gorog, V Fuster - Nature Reviews Cardiology, 2009 - nature.com
… standard dual antiplatelet therapy. These events have been attributed to an … antiplatelet
drug effect or antiplatelet drug 'resistance'. The term drug resistance implies that a drug's

The genetics of antiplatelet drug resistance

G Feher, A Feher, G Pusch, G Lupkovics… - Clinical …, 2009 - Wiley Online Library
… despite adequate antiplatelet therapy. … antiplatelet mechanisms of aspirin and clopidogrel
and the possible role of different polymorphisms, which may affect the efficacy of antiplatelet

Antiplatelet drug resistance: Molecular insights and clinical implications

CN Floyd, A Ferro - Prostaglandins & other lipid mediators, 2015 - Elsevier
… agreement of antiplatelet drug resistance status, there does appear to be concordance that
irrespective of the assay used for its identification, antiplatelet drug resistance is associated …

Antiplatelet drug'resistance'. Part 2: laboratory resistance to antiplatelet drugs—fact or artifact?

DA Gorog, JM Sweeny, V Fuster - Nature Reviews Cardiology, 2009 - nature.com
… of antiplatelet drug resistance with clinical events is presented in detail in Part 1 of this Review.
There is evidence that aspirin resistance, … -resistant patients with cardiovascular disease. …

Antiplatelet drug resistance and variability in response: the role of antiplatelet therapy monitoring

US Tantry, PA Gurbel - Current pharmaceutical design, 2013 - ingentaconnect.com
… For aspirin, the identification of resistance would use a laboratory technique … “resistance
to antiplatelet drugs is more meaningful only when the biochemical phenomenon of resistance

Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4

WC Lau, PA Gurbel - Pharmaceutical research, 2006 - Springer
… clopidogrel resistance has failed to achieve consensus agreement. Currently, the paradigm
antiplatelet drug resistance is accepted as inter-individual response variability to antiplatelet

Antiplatelet drug resistance: not ready for prime time

TL Burns, AN Mooss… - … Pharmacology and Drug …, 2005 - Wiley Online Library
antiplatelet drug resistance in the clinical setting.… antiplatelet drug resistance. Therefore,
recommendations for the screening, diagnosis, and management of antiplatelet drug resistance

Platelet resistance to antiplatelet drugs

A Kumar, J Kao - Recent Patents on Cardiovascular Drug …, 2009 - ingentaconnect.com
antiplatelet drug resistance are not very well understood but are likely multifactorial. Although
the precise definition of antiplatelet drug resistance is … with dual drug resistance were found …

Resistance to antiplatelet drugs: molecular mechanisms and laboratory detection

M Cattaneo - Journal of Thrombosis and Haemostasis, 2007 - Wiley Online Library
… ‘resistance to antiplatelet drugs’ should be limited to situations in which failure of the drug to
… Aspirin resistance, as determined by specific tests (eg serum thromboxane B 2 ), appears to …

Resistance to antiplatelet drugs: current status and future research

US Tantry, KP Bliden, PA Gurbel - Expert opinion on …, 2005 - Taylor & Francis
… , simultaneous use of different antiplatelet drugs that are directed … The main antiplatelet drugs
are aspirin (which inhibits … In recent years, resistance or nonresponsiveness to antiplatelet