Stable self-assembly of bovine α-lactalbumin exhibits target-specific antiproliferative activity in multiple cancer cells

S Mahanta, S Paul - ACS Applied Materials & Interfaces, 2015 - ACS Publications
… In this study, spherical self-assembly of bovine α-lactalbumin (… -based anticancer agent
BAMLET (bovine α-lactalbumin made … α-lactalbumin that exhibits strong inherent antiproliferative

Divergent anticancer activity of free and formulated camel milk α-lactalbumin

VN Uversky, EM El-Fakharany, MM Abu-Serie… - Cancer …, 2017 - Taylor & Francis
α-LA are poorly understood. The goals of the current study were to analyze the anticancer
activity of camel α-… α-LA is able to form complexes with OA with cytotoxic potential, and that the …

Anticancer activity from gold-alpha-lactalbumin nanoconstructs?

SM Lystvet, S Volden, G Singh… - The Journal of …, 2013 - ACS Publications
… Herein, we report the formation of gold-bovine α-lactalbumin nanoconstructs (Au–LA NCs)
displaying conformational changes in the native protein and its concomitant ability to reduce …

Green synthesis, characterization and anticancer activity of luminescent gold nanoparticles capped with apo-α-lactalbumin

DS Yarramala, S Doshi, CP Rao - RSC Advances, 2015 - pubs.rsc.org
… (α-LA) is known to have minimal anti cancer effect, however, shows enhanced anticancer
Therefore, herein, we explore the anticancer activity of apo-α-LA-AuNPs on HeLa (cervical …

[HTML][HTML] Investigation and comparison of the anti-tumor activities of lactoferrin, α-lactalbumin, and β-lactoglobulin in A549, HT29, HepG2, and MDA231-LM2 tumor …

HY Li, P Li, HG Yang, YZ Wang, GX Huang… - Journal of dairy …, 2019 - Elsevier
… reduced by α-lactalbumin. Moreover, the roles of lactoferrin, α-lactalbumin, and β-lactoglobulin
in regulating apoptotic proteins were validated. In summary, lactoferrin, α-lactalbumin, …

Anticancer activity of bovine αlactalbumin treated with microbial transglutaminase

JIEUN JEONG, YHO HONG - International journal of dairy …, 2012 - Wiley Online Library
… This study investigated the effects of bovine α-lactalbumin (α-La) … The anticancer activity for
10 mg/mL of bovine α-lactalbumin (α-… α-La could have anticancer or antiproliferation activity. …

Bioactivity of α-lactalbumin related to its interaction with fatty acids: a review

C Barbana, L Sánchez, MD Pérez - Critical reviews in food science …, 2011 - Taylor & Francis
α-Lactalbumin (α-LA) is a whey protein that has been extensively studied for its folding …
Furthermore, the preparation of an α-LA-oleic acid complex with cytotoxic activity but under …

Growth rates of a human colon adenocarcinoma cell line are regulated by the milk protein alpha-lactalbumin

LG Sternhagen, JC Allen - Bioactive components of human milk, 2001 - Springer
… that bovine a-lactalbumin also has antiproliferative effects in … -lactalbumin was added
to Caco-2 or HT-29 monolayers in amounts from 5 to 35~g/mL. Low concentrations of a-lactalbumin

Supramolecular nanoassembly of lysozyme and α-lactalbumin (apo α-LA) exhibits selective cytotoxicity and enhanced bioavailability of curcumin to cancer cells

P Somu, S Paul - Colloids and Surfaces B: Biointerfaces, 2019 - Elsevier
… Hence SN LYZ-BLA probably did not exhibit anticancer activities in the drug-loaded state;
however, our result showed that SN LYZ-BLA -CUR exhibited higher cytotoxicity than by drug …

ALA‐A2 Is a Novel Anticancer Peptide Inspired by AlphaLactalbumin: A Discovery from a Computational Peptide Library, In Silico Anticancer Peptide Screening and …

T Lerksuthirat, P On‐yam, S Chitphuk… - Global …, 2023 - Wiley Online Library
… -lactalbumin was reported to be inactive for anticancer activity, [ 8 ] but alpha-lactalbumin
discovery of novel ACPs from potential alpha-lactalbumin peptides. An R-based script was …