Emergence of HIV-1 drug resistance during antiretroviral treatment

L Rong, Z Feng, AS Perelson - Bulletin of mathematical biology, 2007 - Springer
… Here we use a mathematical model including both wild-type, ie, drug sensitive, and drug
resistant strains to study the viral load of each strain in the absence of ARV drugs. The model …

Treatment of antiretroviral-drug-resistant HIV-1 infection

SG Deeks - The Lancet, 2003 - thelancet.com
drug-resistant variants. Although there is some controversy about the extent of viral suppression
truly needed to prevent drug resistance… therapy leads to drug resistance and subsequent …

Targeting HIV: antiretroviral therapy and development of drug resistance

L Menendez-Arias - Trends in pharmacological sciences, 2002 - cell.com
… In this context, drug resistance appears to be the inevitable consequence of incomplete …
resistance to RT and PR inhibitors and the molecular mechanisms that lead to drug-resistant

Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis

JZ Li, R Paredes, HJ Ribaudo, ES Svarovskaia… - Jama, 2011 - jamanetwork.com
… Participants were included if all drugs in their ART regimen were fully active by standard
HIV drug resistance testing. Cox proportional hazard models using pooled patient-level data …

Antiretroviral-drug resistance among patients recently infected with HIV

SJ Little, S Holte, JP Routy, ES Daar… - … England Journal of …, 2002 - Mass Medical Soc
… under the selective pressure provided by antiretroviral treatment. Thus, identification of patients
drug resistance and improve the selection of more effective first-line treatment regimens. …

The prevalence of antiretroviral drug resistance in the United States

DD Richman, SC Morton, T Wrin, N Hellmann, S Berry… - Aids, 2004 - journals.lww.com
resistance has been reported in selected cohorts of limited size and geographic representation,
the true prevalence of HIV drug resistance … prevalence of antiretroviral drug resistance in …

[HTML][HTML] Minority HIV-1 drug resistance mutations are present in antiretroviral treatment–naïve populations and associate with reduced treatment efficacy

JA Johnson, JF Li, X Wei, J Lipscomb, D Irlbeck… - PLoS …, 2008 - journals.plos.org
resistance mutations we found at least one minority variant with a different drug resistance
… assessed the impact of three treatment-relevant drug resistance mutations at baseline from …

HIV drug resistance: problems and perspectives

PS Pennings - Infectious disease reports, 2013 - mdpi.com
… pneumoniae isolates in our hospital are carbapenem resistant compared to only sporadic
carbapenem resistant isolates prior to 2009.The purpose of this study was to investigate the …

Antiretroviral therapy and drug resistance in human immunodeficiency virus type 2 infection

L Menéndez-Arias, M Álvarez - Antiviral research, 2014 - Elsevier
… anti-HIV-2 therapies and mutational pathways leading to drug resistance. … ), antiretroviral
drugs and their inhibitory activities, and the mutational pathways leading to drug resistance. …

Public health implications of antiretroviral therapy and HIV drug resistance

MA Wainberg, G Friedland - Jama, 1998 - jamanetwork.com
Resistance to nucleoside-analog antiretroviral drugs among blood donors recently
infected with HIV-1 and naive to antiretroviral treatment. In: Program and abstracts of the 5th …