Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides

KA Lennox, MA Behlke - Nucleic acids research, 2016 - academic.oup.com
… include antisense oligonucleotides (ASOs) and RNA interference (RNAi). Antisense and
RNAi-based gene-knockdown methods vary in efficacy between different cellular compartments…

Making sense of the natural antisense transcript puzzle

RS Reis, Y Poirier - Trends in Plant Science, 2021 - cell.com
antisense transcripts play diverse functions in gene regulation. We propose a general framework
for the initial functional dissection of antisense transcripts… natural antisense transcription

Global analysis of biogenesis, stability and sub-cellular localization of lncRNAs mapping to intragenic regions of the human genome

AC Ayupe, AC Tahira, L Camargo, FC Beckedorff… - RNA biology, 2015 - Taylor & Francis
… of 6,322 intronic and 10,482 antisense monoexonic lncRNAs that map to 5,411 protein
different subcellular compartments, we compared the half-lives of the nuclear-enriched transcripts

… lymphotropic virus type 3 (HTLV-3)-and HTLV-4-derived antisense transcripts encode proteins with similar Tax-inhibiting functions but distinct subcellular localization

É Larocque, M Halin, S Landry, SJ Marriott… - Journal of …, 2011 - Am Soc Microbiol
… we have investigated the presence of antisense transcripts in these new viruses … antisense
transcript. The encoded proteins show distinct localization, with the HTLV-3 antisense protein

[HTML][HTML] Alternative splicing and differential subcellular localization of the rat FGF antisense gene product

SC Zhang, KA MacDonald, M Baguma-Nibasheka… - BMC molecular …, 2008 - Springer
… The present study demonstrates that the antisense RNA itself is translated, and that protein
… are sorted to different subcellular compartments. FGF-2 and its antisense protein are co-…

Predictive models of subcellular localization of long RNAs

B Zuckerman, I Ulitsky - Rna, 2019 - rnajournal.cshlp.org
… (B) Changes in the adjusted R 2 of the regression following omission of different factor groups…
To further evaluate the predictive ability of different features toward subcellular localization, …

Cellular uptake and trafficking of antisense oligonucleotides

ST Crooke, S Wang, TA Vickers, W Shen… - Nature …, 2017 - nature.com
… , localization to different subcellular regions can affect their therapeutic potency. Cellular
uptake … , proteins that result in specific subcellular localizations are proteins that accumulate in …

Alternative splicing of the FGF antisense gene: differential subcellular localization in human tissues and esophageal adenocarcinoma

SC Zhang, C Barclay, LA Alexander… - Journal of Molecular …, 2007 - Springer
antisense (FGF-AS) RNA. The aim of this study was to characterize the expression of alternatively
spliced FGF-AS transcripts … -AS transcripts encoding GFG/NUDT6 isoforms with distinct

Over 20% of human transcripts might form sense–antisense pairs

J Chen, M Sun, WJ Kent, X Huang, H Xie… - Nucleic acids …, 2004 - academic.oup.com
… that SA transcripts have significantly different distribution … in biological process and cellular
localizations. Yelin et al. (14) … SA and other transcripts, probably due to the different strategies …

Antisense transcription in the mammalian transcriptome

S Katayama, Y Tomaru, T Kasukawa, K Waki… - Science, 2005 - science.org
… both partners encode protein, and the transcripts are … two different cellular systems tested,
there was no evidence that ablation of the AS transcript altered the level of the sense transcript