Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides
KA Lennox, MA Behlke - Nucleic acids research, 2016 - academic.oup.com
… include antisense oligonucleotides (ASOs) and RNA interference (RNAi). Antisense and
RNAi-based gene-knockdown methods vary in efficacy between different cellular compartments…
RNAi-based gene-knockdown methods vary in efficacy between different cellular compartments…
Making sense of the natural antisense transcript puzzle
RS Reis, Y Poirier - Trends in Plant Science, 2021 - cell.com
… antisense transcripts play diverse functions in gene regulation. We propose a general framework
for the initial functional dissection of antisense transcripts… natural antisense transcription …
for the initial functional dissection of antisense transcripts… natural antisense transcription …
Global analysis of biogenesis, stability and sub-cellular localization of lncRNAs mapping to intragenic regions of the human genome
… of 6,322 intronic and 10,482 antisense monoexonic lncRNAs that map to 5,411 protein…
different subcellular compartments, we compared the half-lives of the nuclear-enriched transcripts …
different subcellular compartments, we compared the half-lives of the nuclear-enriched transcripts …
… lymphotropic virus type 3 (HTLV-3)-and HTLV-4-derived antisense transcripts encode proteins with similar Tax-inhibiting functions but distinct subcellular localization
É Larocque, M Halin, S Landry, SJ Marriott… - Journal of …, 2011 - Am Soc Microbiol
… we have investigated the presence of antisense transcripts in these new viruses … antisense
transcript. The encoded proteins show distinct localization, with the HTLV-3 antisense protein …
transcript. The encoded proteins show distinct localization, with the HTLV-3 antisense protein …
[HTML][HTML] Alternative splicing and differential subcellular localization of the rat FGF antisense gene product
SC Zhang, KA MacDonald, M Baguma-Nibasheka… - BMC molecular …, 2008 - Springer
… The present study demonstrates that the antisense RNA itself is translated, and that protein
… are sorted to different subcellular compartments. FGF-2 and its antisense protein are co-…
… are sorted to different subcellular compartments. FGF-2 and its antisense protein are co-…
Predictive models of subcellular localization of long RNAs
B Zuckerman, I Ulitsky - Rna, 2019 - rnajournal.cshlp.org
… (B) Changes in the adjusted R 2 of the regression following omission of different factor groups…
To further evaluate the predictive ability of different features toward subcellular localization, …
To further evaluate the predictive ability of different features toward subcellular localization, …
Cellular uptake and trafficking of antisense oligonucleotides
… , localization to different subcellular regions can affect their therapeutic potency. Cellular
uptake … , proteins that result in specific subcellular localizations are proteins that accumulate in …
uptake … , proteins that result in specific subcellular localizations are proteins that accumulate in …
Alternative splicing of the FGF antisense gene: differential subcellular localization in human tissues and esophageal adenocarcinoma
SC Zhang, C Barclay, LA Alexander… - Journal of Molecular …, 2007 - Springer
… antisense (FGF-AS) RNA. The aim of this study was to characterize the expression of alternatively
spliced FGF-AS transcripts … -AS transcripts encoding GFG/NUDT6 isoforms with distinct …
spliced FGF-AS transcripts … -AS transcripts encoding GFG/NUDT6 isoforms with distinct …
Over 20% of human transcripts might form sense–antisense pairs
… that SA transcripts have significantly different distribution … in biological process and cellular
localizations. Yelin et al. (14) … SA and other transcripts, probably due to the different strategies …
localizations. Yelin et al. (14) … SA and other transcripts, probably due to the different strategies …
Antisense transcription in the mammalian transcriptome
S Katayama, Y Tomaru, T Kasukawa, K Waki… - Science, 2005 - science.org
… both partners encode protein, and the transcripts are … two different cellular systems tested,
there was no evidence that ablation of the AS transcript altered the level of the sense transcript…
there was no evidence that ablation of the AS transcript altered the level of the sense transcript…
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