Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms

C Gilbert, J Bestman-Smith, G Boivin - Drug resistance updates, 2002 - Elsevier
Drug-resistant herpesviruses are found relatively … antiviral therapy. For instance, close
to 10% of patients with AIDS receiving intravenous ganciclovir for 3 months excrete a drug-…

Antiviral drugs in current clinical use

E De Clercq - Journal of clinical virology, 2004 - Elsevier
The current armamentarium for the chemotherapy of viral infections consists of 37 licensed
antiviral drugs. For the treatment of human immunodeficiency virus (HIV) infections, 19 …

Antiviral drug resistance: mechanisms and clinical implications

L Strasfeld, S Chou - Infectious Disease Clinics, 2010 - id.theclinics.com
… resistance range from toxicity inherent in use of second-line antivirals, to severe disease …
to antiviral drugs used to treat several viral infections that play a significant role in the clinical

Efficacy of repurposed antiviral drugs: Lessons from COVID-19

MA Martinez - Drug Discovery Today, 2022 - Elsevier
… Several repurposed drugs have been assessed clinically, … New antiviral drugs targeting
different SARS-CoV-2 enzymes … will see the impact of these newly developed drugs on COVID-19…

[HTML][HTML] Potential impact of antiviral drug use during influenza pandemic

R Gani, H Hughes, D Fleming, T Griffin… - Emerging infectious …, 2005 - ncbi.nlm.nih.gov
… However, 2 groups of antiviral drugs are available for the treatment and prophylaxis of …
. Estimated impact of different sizes of antiviral stockpiles on the number of clinical cases at …

Impact of newly available drugs on clinical progression in patients with virological failure after exposure to three classes of antiretrovirals

French Hospital Database on HIV… - Antiviral …, 2005 - journals.sagepub.com
… Thus, the clinical impact of new drugs depended on the number of previous drugs used. VL
and CD4 cell counts measured during follow-up were available for 976 patients. The median …

[HTML][HTML] Candidate antiviral drugs for COVID-19 and their environmental implications: a comprehensive analysis

P Biswas, MM Hasan, D Dey… - … Science and Pollution …, 2021 - Springer
… summarized the epidemiological and clinical data from several clinical trials conducted since
… The restrictions on travel and businesses significantly impacted the economic condition, …

[HTML][HTML] Antiretroviral drugs impact autophagy with toxic outcomes

L Cheney, JM Barbaro, JW Berman - Cells, 2021 - mdpi.com
… highlights the gaps in our knowledge of the impacts of antiretroviral drugs on autophagy. …
impact of antiretroviral drugs on autophagy as they relate to clinical side effects and toxicities. …

The importance of resistance to direct antiviral drugs in HCV infection in clinical practice

C Sarrazin - Journal of hepatology, 2016 - Elsevier
… time, susceptibility to additional antiviral agents is reduced or duration of treatment is
suboptimal. In this review geno- and phenotypic resistance testing as well as clinical data on the …

Impact of therapeutic drug monitoring of antiretroviral drugs in routine clinical management of people living with HIV: a narrative review

D Cattaneo, S Baldelli, V Cozzi… - Therapeutic Drug …, 2020 - journals.lww.com
… Increasingly, the management of comorbidities, polypharmacy, and drugdrug interaction,
and their impact on antiretroviral therapy will have to be undertaken. These clinical settings …