Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations.

E Boerwinkle, CC Leffert, J Lin… - The Journal of …, 1992 - Am Soc Clin Investig
apo(a) mRNA and gene structure (26-28). In attempt to devise a way to measure the size ofthe
apo(a) gene … a large restriction fragment from the apo(a)gene which contains most, ifnot all…

The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration

HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
… In order to obtain a deeper insight into the genetic regulation of plasma Lp(a) levels, we …
the apo(a) size polymorphism and have related the genetic variation at the apo(a) locus to apo(a…

APO E gene and gene-environment effects on plasma lipoprotein-lipid levels

JM Hagberg, KR Wilund… - Physiological genomics, 2000 - journals.physiology.org
… total cholesterol levels more in APO E4 than in APO E2 or E3 individuals. Both … APO E2 and
E3 individuals improve plasma lipoprotein-lipid profiles more with exercise training than APO

Polymorphism in the apolipoprotein (a) gene, plasma lipoprotein (a), cardiovascular disease, and low-dose aspirin therapy

DI Chasman, D Shiffman, RYL Zee, JZ Louie, MM Luke… - Atherosclerosis, 2009 - Elsevier
… A minor allele variant (rs3798220) of apolipoprotein(a) has been reported to be
associated with elevated plasma lipoprotein(a) [Lp(a)] and increased cardiovascular risk. We …

[HTML][HTML] Plasma lipoproteins: apolipoprotein structure and function.

RW Mahley, TL Innerarity, SC Rall Jr… - Journal of lipid …, 1984 - Elsevier
… The apolipoprotein constituents of the major plasma lipoproteins … that the apolipoproteins of
the various lipoproteins regulate … chromosome 19 the gene for apolipoprotein CII. Proc. Natl. …

The mysteries of lipoprotein (a)

G Utermann - Science, 1989 - science.org
… in the hypervariable apo(a) gene on chromosome 6q2.6-q2.7 and interaction of apo(a) alleles
with defective LDLreceptor genes explain a large fraction ofthe variability of plasma Lp(a) …

Sequence polymorphisms in the apolipoprotein (a) gene. Evidence for dissociation between apolipoprotein (a) size and plasma lipoprotein (a) levels.

JC Cohen, G Chiesa, HH Hobbs - The Journal of clinical …, 1993 - Am Soc Clin Investig
… in plasma Lp(a) concentrations were due to sequence variations in the apo(a) gene, we
examined the sequences of apo(a) alleles in 23 individuals homozygous for same-sized apo(a) …

Pentanucleotide TTTTA repeat polymorphism of apolipoprotein (a) gene and plasma lipoprotein (a) are associated with ischemic and hemorrhagic stroke in Chinese …

L Sun, Z Li, H Zhang, A Ma, Y Liao, D Wang, B Zhao… - Stroke, 2003 - Am Heart Assoc
… The PNTR polymorphism of the apo(a) gene was determined … Low-number repeats (sum
of both alleles <16) of apo(a) … first time that low numbers of apo(a) PNTR and plasma Lp(a) …

Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans

MJ Graham, N Viney, RM Crooke, S Tsimikas - Journal of lipid research, 2016 - ASBMB
… Because human cell lines do not adequately express the apo(a) gene, an apo(a) expression
vector containing the 5′-untranslated region, the signal sequence, the first five KIV-like …

Polymorphisms in the apolipoprotein (a) gene and their relationship to allele size and plasma lipoprotein (a) concentration

LH Puckey, RM Lawn, BL Knight - Human molecular genetics, 1997 - academic.oup.com
… sites at the apolipoprotein(a) gene locus have … plasma lipoprotein(a) concentrations
investigated. There was strong linkage disequilibrium between sites at the 5′-region of the gene