Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations.
E Boerwinkle, CC Leffert, J Lin… - The Journal of …, 1992 - Am Soc Clin Investig
… apo(a) mRNA and gene structure (26-28). In attempt to devise a way to measure the size ofthe
apo(a) gene … a large restriction fragment from the apo(a)gene which contains most, ifnot all…
apo(a) gene … a large restriction fragment from the apo(a)gene which contains most, ifnot all…
The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration
HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
… In order to obtain a deeper insight into the genetic regulation of plasma Lp(a) levels, we …
the apo(a) size polymorphism and have related the genetic variation at the apo(a) locus to apo(a…
the apo(a) size polymorphism and have related the genetic variation at the apo(a) locus to apo(a…
APO E gene and gene-environment effects on plasma lipoprotein-lipid levels
JM Hagberg, KR Wilund… - Physiological genomics, 2000 - journals.physiology.org
… total cholesterol levels more in APO E4 than in APO E2 or E3 individuals. Both … APO E2 and
E3 individuals improve plasma lipoprotein-lipid profiles more with exercise training than APO …
E3 individuals improve plasma lipoprotein-lipid profiles more with exercise training than APO …
Polymorphism in the apolipoprotein (a) gene, plasma lipoprotein (a), cardiovascular disease, and low-dose aspirin therapy
DI Chasman, D Shiffman, RYL Zee, JZ Louie, MM Luke… - Atherosclerosis, 2009 - Elsevier
… A minor allele variant (rs3798220) of apolipoprotein(a) has been reported to be
associated with elevated plasma lipoprotein(a) [Lp(a)] and increased cardiovascular risk. We …
associated with elevated plasma lipoprotein(a) [Lp(a)] and increased cardiovascular risk. We …
[HTML][HTML] Plasma lipoproteins: apolipoprotein structure and function.
RW Mahley, TL Innerarity, SC Rall Jr… - Journal of lipid …, 1984 - Elsevier
… The apolipoprotein constituents of the major plasma lipoproteins … that the apolipoproteins of
the various lipoproteins regulate … chromosome 19 the gene for apolipoprotein CII. Proc. Natl. …
the various lipoproteins regulate … chromosome 19 the gene for apolipoprotein CII. Proc. Natl. …
The mysteries of lipoprotein (a)
G Utermann - Science, 1989 - science.org
… in the hypervariable apo(a) gene on chromosome 6q2.6-q2.7 and interaction of apo(a) alleles
with defective LDLreceptor genes explain a large fraction ofthe variability of plasma Lp(a) …
with defective LDLreceptor genes explain a large fraction ofthe variability of plasma Lp(a) …
Sequence polymorphisms in the apolipoprotein (a) gene. Evidence for dissociation between apolipoprotein (a) size and plasma lipoprotein (a) levels.
JC Cohen, G Chiesa, HH Hobbs - The Journal of clinical …, 1993 - Am Soc Clin Investig
… in plasma Lp(a) concentrations were due to sequence variations in the apo(a) gene, we
examined the sequences of apo(a) alleles in 23 individuals homozygous for same-sized apo(a) …
examined the sequences of apo(a) alleles in 23 individuals homozygous for same-sized apo(a) …
Pentanucleotide TTTTA repeat polymorphism of apolipoprotein (a) gene and plasma lipoprotein (a) are associated with ischemic and hemorrhagic stroke in Chinese …
L Sun, Z Li, H Zhang, A Ma, Y Liao, D Wang, B Zhao… - Stroke, 2003 - Am Heart Assoc
… The PNTR polymorphism of the apo(a) gene was determined … Low-number repeats (sum
of both alleles <16) of apo(a) … first time that low numbers of apo(a) PNTR and plasma Lp(a) …
of both alleles <16) of apo(a) … first time that low numbers of apo(a) PNTR and plasma Lp(a) …
Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans
MJ Graham, N Viney, RM Crooke, S Tsimikas - Journal of lipid research, 2016 - ASBMB
… Because human cell lines do not adequately express the apo(a) gene, an apo(a) expression
vector containing the 5′-untranslated region, the signal sequence, the first five KIV-like …
vector containing the 5′-untranslated region, the signal sequence, the first five KIV-like …
Polymorphisms in the apolipoprotein (a) gene and their relationship to allele size and plasma lipoprotein (a) concentration
LH Puckey, RM Lawn, BL Knight - Human molecular genetics, 1997 - academic.oup.com
… sites at the apolipoprotein(a) gene locus have … plasma lipoprotein(a) concentrations
investigated. There was strong linkage disequilibrium between sites at the 5′-region of the gene …
investigated. There was strong linkage disequilibrium between sites at the 5′-region of the gene …
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