Deficiency of Bid protein reduces sepsis-induced apoptosis and inflammation, while improving septic survival

CS Chung, F Venet, Y Chen, LN Jones, DC Wilson… - Shock, 2010 - journals.lww.com
… mitochondrial-driven apoptosis during sepsis remains largely … versus nonimmune cell
apoptosis as seen in sepsis is less well … on sepsis-induced mortality, apoptosis, and inflammation. …

Pathophysiologic mechanisms in septic shock

EG King, GJ Bauzá, JR Mella, DG Remick - Laboratory investigation, 2014 - nature.com
apoptosis is a potential reason that septicinflammatory in vitro models such as Haemophilus
somnus and LPS have been shown to be associated with endothelial cell apoptosis. …

Structural changes of the heart during severe sepsis or septic shock

L Smeding, FB Plötz, ABJ Groeneveld, MCJ Kneyber - Shock, 2012 - journals.lww.com
… basis of inflammatory myocardial edema during experimental sepsis ( 41, 42 ). … sepsis,
myocardial apoptosis was found both through activation of the extrinsic and the intrinsic apoptotic

Apoptotic cells protect mice against lipopolysaccharide-induced shock

Y Ren, Y Xie, G Jiang, J Fan, J Yeung, W Li… - The Journal of …, 2008 - journals.aai.org
… states in vivo and the significance in vivo of reducing inflammatory reaction remain to be …
resembling septic shock in humans (20, 21). We investigated the protective effect of apoptotic

Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome

L Fialkow, L Fochesatto Filho, MC Bozzetti, AR Milani… - Critical Care, 2006 - Springer
… Recent studies suggest that neutrophil apoptosis is decreased in systemic inflammatory
the mean percentage of neutrophil apoptosis of uncomplicated sepsis, septic shock, ARDS, and …

Apoptosis–role in infection and inflammation

WC Liles - Current opinion in infectious diseases, 1997 - journals.lww.com
apoptosis can serve as a mechanism to terminate or suppress an unbridled inflammatory
response during sepsis… to superantigen-mediated septic shock. These findings further …

Insights into the apoptotic death of immune cells in sepsis

Y Luan, Y Yao, X Xiao, Z Sheng - Journal of Interferon & Cytokine …, 2015 - liebertpub.com
… modalities as well as therapeutic strategies for severe sepsis or septic shock. It is generally
accepted that sepsis is an inflammatory state resulting from the systemic response to infection…

Molecular biology of inflammation and sepsis: a primer

I Cinel, SM Opal - Critical care medicine, 2009 - journals.lww.com
… the molecular biology of sepsis, severe sepsis, and septic shock. … sepsis ( 90 ). Neutrophils
are constitutively proapoptotic and apoptosis is fundamental for the resolution of inflammation

Role of apoptotic cell death in sepsis

RS Hotchkiss, KW Tinsley, IE Karl - Scandinavian journal of …, 2003 - Taylor & Francis
… In contrast, inflammation is not typical of apoptosis because phagocytic cells … apoptosis
is rapidly increased in the blood of patients with septic shock, and that lymphocyte apoptosis

The pathophysiology of septic shock

OO Nduka, JE Parrillo - Critical Care Nursing Clinics, 2011 - ccnursing.theclinics.com
… in septic shock. Studies support the observation that defective NFκB signaling leads to
immunosuppression in sepsis, favoring apoptosis … of inflammation and apoptosis following PAMP/…