… Recently, interest has focused on the interaction of inflammation and apoptosis. Mitochondrial
… Eighteen patients who fulfilled severe sepsis and septic shock criteria, as described by …

… system is beneficial to the host by down-regulating the inflammatory response to sepsis. …
apoptosis in human septic shock is associated with poor outcome. Shock 2002; 18:487–94. …

… In view of this, it is important to understand the contribution of apoptosis to neutrophil
mediINTRODUCTION ated inflammatory responses in the setting of sepsis or shock. …

… Sepsis and septic shock are characterized by prolonged inflammation and delayed …
discoveries placed forth the intrinsic apoptotic pathway in regulation of neutrophil apoptosis. …

… study of caspase activation patterns in apoptotic lymphocytes isolated from baboons with
E. coli-induced septic shock [114] as well as a large series of human sepsis patients [115] are …

… is typically referred to as “septic shock” in which the circulatory … inflammatory response
thought to be due to immune cell … of acute inflammation and the role of apoptosis in the tissue. Cli…

… to prevent apoptosis in vitro, we evaluated their effect on survival, lymphocyte apoptosis, and
… stimulates immune tolerance by the release of anti-inflammatory cytokines, including IL-6 …

… and changes in Bax and Bcl-2 regulation in response to experimental sepsis. Apoptosis of
… We, therefore, conclude that sepsis-induced apoptosis of intraparenchymal brain cells is, at …

… role in myocardial apoptosis during sepsis. Severe sepsis and septic shock are the leading
… myocardial activity and inflammatory responses. Am J Physiol Heart Circ Physiol 2006; 291: …

… of inflammation differentiates apoptosis from … septic shock, direct application of TNF-α caused
apoptosis in hepatocytes [106]. Further support for the role of apoptosis in endotoxic shock …