… pathway is fundamental to the pathophysiology of many hematologic malignancies. … apoptotic
pathway, which has been effectively targeted therapeutically in hematologic malignancies…

… apoptosis in hematological malignancies. Thus, it is important to discuss the role that caspases
play in GC-induced apoptotic signaling in normal and malignant hematological … apoptosis …

… induce DNA fragmentation and apoptosis of thymocytes and the … of the core components of
the apoptosis machinery at the … far identified within the core apoptotic machinery and describe …

… hematologic malignancies resulted in one patient with AML achieving complete remission
(CR), and 3/14 patients showed hematologic … Preclinical studies in hematologic malignancies …

… Apoptotic pathways, molecules involved in the cross-talk between individual apoptosis
pathways … directly or indirectly apoptosis of hematologic cancer cells, are reviewed in this article. …

… apoptosis coupled with malignant transformation may result in the development of leukemia
and lymphoma. Oncogenic mutations that block apoptosis … that can promote apoptosis, such …

… Targeting apoptotic pathways in hematological malignancies. In response to cell damage, …
interaction between anti-apoptotic (such as Bcl-2) and multi-domain pro-apoptotic (mainly Bax …

… to apoptosis in a vast range of hematologic malignancies. … ; p52 activity can result in apoptosis
inhibition in some systems. … might contribute to apoptosis suppression in neoplastic cells. …

… on the expression of IAPs in hematological malignancies as a potential treatment target. …
of selective, apoptosisinducing treatment of hematological malignancies. Small molecule IAP …

… Alterations in the expression of apoptosis-related proteins are a common observation in
hematologic malignancies. Moreover, increased expression levels of certain apoptosis-related …