… of caspase-8 as a critical apoptotic caspase effector of death-… –Burkitt lymphoma cells lacking
caspase-8 are not completely … the apoptotic effectors caspase-3 and caspase-7, after which …

… novel function for caspase-8 as an orchestrator of not only apoptosis but also differentiation
… amino-terminal death effector domains, and does not require caspase-8 catalytic activity. The …

… In the intrinsic, or mitochondrial pathway of apoptosis, effector caspases are activated
after a signaling cascade involving mitochondrial outer membrane permeabilization (MOMP), …

… We outline non-apoptotic functions for caspase-8, including its ability to repress necroptosis,
… and activation of downstream effector caspases, caspase-3 and caspase-7. Formation of …

… of apoptosis (IAP) protein degradation to promote caspase-8-… to NLRP3 inflammasome-mediated
caspase-1-dependent IL-… activation, the apoptotic executioner caspases, caspase-3 …

… caspases such as caspase-8 could … caspase activity and apoptosis, we searched public
databases for expressed sequence tags (ESTs) that encode proteins with homology to caspase-8…

… which relies on caspase-8 DED chain … caspase-8 DED chain formation within the complex
and demonstrate that preventing caspase-8 chain formation blocks activation of the caspase …

… , deletion of caspase-8 in hepatocytes protected them from Fas-induced caspase activation
… to investigate the cause of death of caspase-8 knockout embryos revealed that this enzyme …

… An argument can be made that caspase-8 may be classified as both an apoptotic and an …
activation and recruitment domain (CARD), whereas caspase-8 and −10 have a death effector …

… caspase-8 is indeed activated after exposure to this toxin early in the course of cell demise,
suggesting that caspase-8 … broad-spectrum and specific caspase-8 inhibitors did not result in …