Mitochondrial dysfunction as a mediator of hippocampal apoptosis in a model of hepatic encephalopathy

J Bustamante, S Lores-Arnaiz, S Tallis… - Molecular and cellular …, 2011 - Springer
apoptotic pathways. These stimuli can activate different cell receptors inducing different
pathways … the pro-apoptotic members of the Bcl-2 family, leading to alteration of the pro and anti …

Hepatic encephalopathy: from metabolic to neurodegenerative

R Ochoa-Sanchez, F Tamnanloo, CF Rose - Neurochemical research, 2021 - Springer
apoptotic pathway activation, and neurite degeneration, along with an increased expression
of apoptotic … ammonia leads to the activation of apoptotic pathways particularly in neurons, a …

Naringenin mitigates thioacetamide-induced hepatic encephalopathy in rats: Targeting the JNK/Bax/caspase-8 apoptotic pathway

SM Eraky, DH El-Kashef, M El-Sherbiny… - Food & Function, 2023 - pubs.rsc.org
… in the hepatic tissue. Thus, we investigated in depth the apoptosis pathway (pro-BDNF/SORT1,
c-… -8, and BDNF) underlying the TAA-induced HE on both hepatic and cerebral tissues. …

Cellular pathogenesis of hepatic encephalopathy: An update

K Lu - Biomolecules, 2023 - mdpi.com
… that inhibition of the egl-9 family hypoxia-inducible factor 3 (EGLN3) can effectively regulate
the mitochondrial apoptotic pathway and reduce ammonia toxicity-induced apoptosis [34]. …

Nifuroxazide attenuates experimentally-induced hepatic encephalopathy and the associated hyperammonemia and cJNK/caspase-8/TRAIL activation in rats

AE Khodir, E Said - Life sciences, 2020 - Elsevier
… Nevertheless, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)
initiates pathways of cell death in which caspase activation is mediated either directly or …

[HTML][HTML] Hepatic encephalopathy: an approach to its multiple pathophysiological features

JC Perazzo, S Tallis, A Delfante, PA Souto… - World journal of …, 2012 - ncbi.nlm.nih.gov
… to urea, shifting this metabolic pathway to the muscular system … feature of apoptosis, known
as apoptotic volume decrease (… apoptotic stimuli and seems to be a prerequisite for apoptosis

Carvedilol attenuates brain damage in mice with hepatic encephalopathy

K Amirshahrokhi, A Niapour - International Immunopharmacology, 2022 - Elsevier
… induced Nrf2/HO-1 pathway. Carvedilol inhibited the activity of … Moreover, the ratio of Bcl2/Bax
was increased and apoptotic cell … and inhibition of inflammatory and apoptotic pathways. …

[PDF][PDF] Gene expression profiling in the cerebral cortex of patients with cirrhosis with and without hepatic encephalopathy

B Görg, HJ Bidmon, D Häussinger - Hepatology, 2013 - Wiley Online Library
… eight patients with liver cirrhosis and accompanying HE who died while in hepatic coma (HE …
potentially involved in apoptosis, such as TRAIL and caspases 1, 6, and 8, but also of anti-…

Pathogenesis of hepatic encephalopathy in chronic liver disease

R Ochoa-Sanchez, CF Rose - Journal of clinical and experimental …, 2018 - Elsevier
Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome that occurs during
chronic liver disease (CLD). While ammonia and other precipitating factors in …

Alogliptin abates memory injuries of hepatic encephalopathy induced by acute paracetamol intoxication via switching-off autophagy-related apoptosis

MA Saad, AA Rastanawi, MF El-Yamany - Life sciences, 2018 - Elsevier
Hepatic encephalopathy is a potentially reversible or … [6] Moreover, hepatic encephalopathy
due acute liver damage occurs … p53 enhances apoptosis through upregulation of TRAIL and …