… A double mutation in APP exon 16 We decided to sequence exons 16 and 17 of the APP
gene as these encode ß-amyloid. Two base pair (bp) transversions (G to T and A to C) were …

… Early-onset fAD, which represents <1% of AD cases, is caused by rare and fully
penetrant mutations in three different genes encoding β-amyloid precursor protein (APP) on …

… Finally, recent molecular genetic investigations have identified a variety of mutations in …
of APP and Aβ in the context of AD.—Sisodia, SS, Price, DL Role of the β‐amyloid protein in …

… Then, the results showed that expression of the APP gene is under epigenetic regulation
caused by genetic and environmental factors as well as life events and aging [3],[18]–[20], and …

… genetic background impacts several steps leading from APP processing to Aβ metabolism
and Aβ deposition. First, the choice between α- and β-secretase cleavage in APP … CTF β in the …

… Here, we have examined the impact of dietary cholesterol and apoE on APP processing
and Aβ levels using the APP gene-targeted mice. Cholesterol is an integral component of all …

… missense mutation at codon 717 of APP was identified in the two … APP gene was the first
identified causative gene for FAD (Table I). This established a view that AD is not a single-gene …

… The APP21 rat line expresses high levels of human APP and could be a … of APP gene
regulation. Determination of the elements that are responsible for tissue-specific expression of APP …

… To determine whether developmental exposure to Pb resulted in long-term alterations in
the expression of APP, we examined the lifelong expression of the APP gene. We also …

… regulation of the amyloid precursor protein (APP) from which … to any changes in APP
metabolism and miRNAs function at … either in the APP gene itself or in the PSEN1 and 2 genes that …