… in alternative APP pre-mRNA splicing and in the control of genomic rearrangements of the
APP gene, … The APP-promoter sequence indicates that the APP gene belongs to the class of …

… To further confirm the inhibitory effect of thyroid hormones on APP gene expression we
next examined the APP mRNA levels in the brain of euthyroid and hypothyroid newborn rats. …

… These two sites, particularly the AβID within the APP promoter, form the basis of our … AβID
on the APP gene (APP) promoter sequence at -3831, and BACE1 gene promoter sequences at …

… Gene expression; Anterior horn cell; Dorsal root ganglion; Alzheimer's disease The fl-amyloid
precursor protein (APP… We studied the regulation of APP gene expression in a paradigm of …

… The expression of the β-amyloid precursor protein (APP), which plays a key role in the …
negatively regulate the expression of the APP gene in neuroblastoma cells. Transient transfection …

… Besides identifying a novel NEP-like enzyme that controls Aβ in vivo, our results have
implications for potential therapeutic applications. Experiments using NEP gene therapy have …

… include direct and indirect genetic and other risk factors for AD, APP processing, and …
amyloid precursor protein (APP), the biochemistry and biology of its proteolytic product, amyloid β …

… A correlation between APP overexpression and development of β-amyloid deposits is found
… extra copy of the APP gene. These individuals show a 50% overexpression of APP mRNA ( …

… The amyloid precursor protein (APP) plays a key role in the pathogenesis of Alzheimer’s
disease (AD), as proteolytical cleavage of APP gives rise to the β-amyloid peptide which is …

… The sequences that are effective to silence APP SW and APP LON as identified in this study
may be useful in both in vivo and in vitro studies to investigate the pathophysiological role of …