… The APP gene is located on chromosome 21 in humans with three major isoforms arising
from alternative splicing [3]. These are APP695, APP751 and APP770 (containing 695, 751, …

… propose that Alzheimer's disease (AD) is a single disease with a common metabolic APP(…
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of 8…

… Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has
arisen from the application of molecular and cell biology to this complex disorder of the limbic …

… The Kunitztype serine protease inhibitory sequence (KPI) in the APP gene diverged from
its ancestral gene about 270 million years ago and was inserted into the gene soon after …

… other genes associated with Alzheimer's disease … Alzheimer's disease, and this duality may
well explain the close links between vascular and cerebral pathology in Alzheimer's disease. …

… of the genes involved in AD. First, we sequenced the presenilins and APP genes in a large
… Then, in order to have a better knowledge of genetic variation within these genes, we have …

… Historically, Alzheimer's disease (AD) is … genetics of Alzheimer's disease is complex and
heterogeneous. Most cases are “sporadic” with no apparent familial recurrence of the disease. …

… A double mutation in APP exon 16 We decided to sequence exons 16 and 17 of the APP
gene as these encode ß-amyloid. Two base pair (bp) transversions (G to T and A to C) were …

… Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for the
… transcripts from the single APP gene results in several isoforms of the gene product. APP695…

… Alzheimer’s disease-related gene APP, … Alzheimer’s disease showed increased gencDNA
diversity, including eleven mutations known to be associated with familial Alzheimer’s disease …