… inbred APP transgenic rat line with high APP expression in the brain, as we believe this may
be one of the important prerequisites for producing amyloid pathology in rat models of AD. …

… This can be attributed to moderate levels of APP gene expression. However, UKUR25
and UKUR28 transgenic rat strains showed an important accumulation of intracellular Aβ (iAβ)-…

… (A) An example of the PCR confirmation of production of transgenic rats possessing the
human APP gene, marked by an asterisk. + and – indicates positive and negative controls, …

… Double transgenic mice with this genetic alteration are generated by the co-expression of
APP swe and PS1 deleted at exon 9 (APPswe/PS1dE9). As in human pathology, diffuse “…

… a transgenic rat model overexpressing transgenes with three, familial AD mutations (two in
APP … Very recently, a fourth transgenic rat expressing Swedish mutant human APP has been …

… mutation in the gene encoding the amyloid precursor protein (APP) and … APP gene, were
found to be unsatisfactory, and double transgenic mice carrying two human mutated transgenes…

… the 5′ flanking sequence of the rat synapsin I gene (Syn I) containing promoter sequences
… as in the present study, rats expressing APP transgenes demonstrated low and inadequate …

… Other APP and PS tg models have been developed in rats, … the APP gene that are utilized
in the generation of animal models of AD. Mutations in the N- and C-terminal domains of APP …

… rats showed elevated APP gene expression, significantly more dense APP deposits in
cytoplasm of neural cells, and APP-… We studied APP attributes in aged rats, using brain tissue …

… -APP transgenic rat, which expresses the mutated human amyloid precursor protein (APP)
gene, … of iAβ build-up on neuronal inflammatory gene expression. We demonstrate that key …