… Mitochondria are abundant in the female germ line (oocytes) and play an important role in
… embryonic development via fertilization, where mitochondrial biogenesis is arrested. Rapid …

… embryonic cleavage stages, highly polarized mitochondria … (TUNEL) assay in human
arrested embryos. Molecular Human … of abnormal or arrested human preimplantation embryos. …

… , leaves the mitochondrial genome particularly … mitochondrial gene expression in oocytes
that fail to fertilise after exposure to sperm and in embryos that undergo developmental arrest…

… shown that the mitochondrial gene transcription levels are significantly decreased in unfertilized
oocytes and arrested embryos compared with 3PN embryos [22], and embryos may fail …

… with embryo arrest and apoptosis Because both radical dot O 2 − and H 2 O 2 are involved in
embryo arrest… Indeed, transactivation of target genes involved in genotoxic stress response …

… in mouse embryos causes an early developmental arrest between embryonic days 7.5 and
… capable of maintaining mtDNA in mammalian mitochondria. In addition, presence of Polg is …

… I propose that the imperative of conserving the mitochondrial genome could be a … failure to
conceive with IVF/embryo transfer), then slow or arrested cleavage in vitro, fertilization failure, …

… Mitochondrial and non-mitochondrial PHGPx and sperm nuclei GPx are transcribed from …
Arrest of gastrulation and the reduced size of mutant embryos might be accounted for in a …

… In addition, unfertilizable oocytes and developmentally arrested embryos show a decreased
expression of mitochondrial genes and an increased presence of the 4977 bp deletion [72–…

… that null embryos from each Mrp allele arrested prior to … These data support the hypothesis
that E7.5 mutant embryos … these five Mrp genes results in developmental arrest and failure to …