… role of mitochondria and their genome during oogenesis and early embryo development. …
, perhaps related to the prolonged cell cycle arrest experienced by the female gamete. A recent …

… to mitochondria, we performed dual labelling immunocytochemistry. As can been seen in
Figure 5F, Hrk did not localize to mitochondria, … to select non‐arrested embryos, increases …

… of a non-mitochondrial genetic disorder (17 embryos: 7 whole arrested embryos and 10
sampled embryos affected by a non-mitochondrial disorder, Supplementary Material, Table S1). …

… In fact, in the CCs corresponding to embryos with arrested development, we detected a
significantly decreased expression of both COXII and MT-ATP6, markers of mitochondrial …

… Following fertilization, the embryonic genome activates during the first days postfertilization
… species-specific embryonic genome activation (EGA). In human embryos, paternal transcripts …

… Thus, replication of the mitochondrial genome is linked in some way to the … mitochondria in
the cells of the early embryo at a period when mitochondrial biogenesis is slowed or arrested. …

… arrest within mitochondria, either directly or indirectly, is difficult to approach in vivo with the
intact embryo… the major proteins encoded by the mitochondrial genome are few in number, …

… mitochondria are found in normal cleaving embryos, the mitochondria from developmentally
arrested embryos … The mitochondrial genetic bottleneck is one of the most important …

… % of arrested or fragmented embryos, and 21.1% of 3PN embryos … , ND6 and Cyt b genes in
oocytes and embryos revealed that the … oocytes than in arrested embryos and 3PN embryos. …

… Since the level of mtDNA remains the same up to the blastocyst stage, the authors
conclude that there exists an arrest of mtRNA synthesis in early embryos and that the steady-state …