A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination regimens

DA Elsherbiny, SA Asimus, MO Karlsson… - … of pharmacokinetics and …, 2008 - Springer
… the inductive properties of artemisinin antimalarials using … turn-over models for induction,
were described by nonlinear … and during ten days of artemisinin administration. Sparse data (…

[HTML][HTML] Antimalarial and anticancer properties of artesunate and other artemisinins: current development

P Khanal - Monatshefte für Chemie-Chemical Monthly, 2021 - Springer
… other artemisinins as antimalarial drugs and their uses in cancer therapy. Artesunate is an
artemisinin … of artesunate and other anti-malaria drugs used to treat severe falciparum malaria. …

The Anti-infective and Anti-cancer Properties of Artemisinin and its Derivatives

CP Hencken, AS Kalinda, JG D'Angelo - Annual Reports in Medicinal …, 2009 - Elsevier
… ,2,4-trioxane class of antimalarials, including artemisinin, exert … artemisinin's antimalarial
activity has been well-established. … a transferrin receptor–dependent induction of apoptosis [67]. …

Toxicity of the antimalarial artemisinin and its dervatives

T Efferth, B Kaina - Critical reviews in toxicology, 2010 - Taylor & Francis
… , but also on the chemical properties of the compounds, which … be appearing due to apoptosis
induction in normal cells. Cell … for combinations with established antimalarials, but also for …

Why artemisinin and certain synthetic peroxides are potent antimalarials. Implications for the mode of action

CW Jefford - Current medicinal chemistry, 2001 - ingentaconnect.com
… of evidence that artemisinin (14), its lactol derivatives 18-22 and peroxidic antimalarials kill
the malarial parasite in the blood of the host by a stepwise process of chemical induction Fig. (…

[HTML][HTML] Biological actions of artemisinin: insights from medicinal chemistry studies

J Li, B Zhou - Molecules, 2010 - mdpi.com
… malaria parasites to existing antimalarial drugs such as chloroquine, quinine and mefloquine
… about the chiral properties of artemisinin because a strong and specific interaction between …

Antimalarial and anticancer activities of artemisinin–quinoline hybrid-dimers and pharmacokinetic properties in mice

MC Lombard, DD N'Da, JC Breytenbach… - European journal of …, 2012 - Elsevier
… of artemisinin-based antimalarials have provided a new class of highly effective
antimalarials which have become the most important class of drugs now used as artemisinin-based …

Artemisinin-derived dimers: potent antimalarial and anticancer agents

T Fröhlich, A Çapcı Karagöz, C Reiter… - Journal of medicinal …, 2016 - ACS Publications
… free radicals and ROS and induction of oxidative stress, DNA … than artemisinin and 21 to
354-fold more active than chloroquine. … , the required properties or structural characteristics for a …

[HTML][HTML] Review of pyronaridine anti-malarial properties and product characteristics

SL Croft, S Duparc, SJ Arbe-Barnes, JC Craft, CS Shin… - Malaria journal, 2012 - Springer
… to other anti-malarials, including chloroquine. Resistance to … is used in combination with
other anti-malarials, in particular, … and vivax malaria in artemisinin-combination therapy. Clinical …

Artemisone—a highly active antimalarial drug of the artemisinin class

RK Haynes, B Fugmann, J Stetter… - Angewandte Chemie …, 2006 - Wiley Online Library
… such properties are countered by selective uptake into parasitized erythrocytes. Their induction
… compounds 9–18 against Plasmodium falciparum chloroquine (CQ)-sensitive D6 or 3D7 …