[HTML][HTML] Transmembrane signaling by a synthetic receptor in artificial cells

AB Søgaard, AB Pedersen, KB Løvschall… - Nature …, 2023 - nature.com
… of artificial cells, we engineer fully synthetic receptors with the capacity of transmembrane
signaling, using tools of chemistry. Our receptors … The main difference from natural receptors is …

Artificial cells: synthetic compartments with life-like functionality and adaptivity

BC Buddingh', JCM van Hest - Accounts of chemical research, 2017 - ACS Publications
artificial cells. In this Account, we highlight our recent work and that of others on the construction
of artificial cells. … these have been imitated in artificial cells. First, compartmentalization is …

Synthesis of an artificial cell surface receptor that enables oligohistidine affinity tags to function as metal-dependent cell-penetrating peptides

S Boonyarattanakalin, S Athavankar… - Journal of the …, 2006 - ACS Publications
cells to internalize proteins fused to common oligohistidine affinity tags, we synthesized an
artificial cell surface receptor … This synthetic receptor inserts into cellular plasma membranes, …

Artificial cells: past, present and future

W Jiang, Z Wu, Z Gao, M Wan, M Zhou, C Mao… - ACS nano, 2022 - ACS Publications
… on the development of artificial cells and their properties and applications. Artificial cells are
derived from lipids, polymers, lipid/polymer hybrids, natural cell membranes, colloidosome, …

Artificial cell surface constructs for studying receptor–ligand contributions to lymphocyte activation

J Curtsinger, MJ Deeths, P Pease… - Journal of immunological …, 1997 - Elsevier
… Non-membrane proteins, such as anti-receptor antibodies, can be immobilized in a similar
… These artificial cell surface constructs can be handled in the same way as cells, including …

Use of artificial cells as drug carriers

SE Diltemiz, M Tavafoghi, NR De Barros… - Materials chemistry …, 2021 - pubs.rsc.org
… in the development of artificial cells as DDSs, highlighting how their designs have been
inspired by natural cells or cell membranes. Advancement of artificial cell technologies has led to …

Designing artificial cells towards a new generation of biosensors

MA Boyd, NP Kamat - Trends in biotechnology, 2021 - cell.com
… Here, we focus on recent progress toward stimuli-responsive artificial cells and discuss
strategies for membrane functionalization in order to expand cell-free biosensing capabilities and …

Building a synthetic mechanosensitive signaling pathway in compartmentalized artificial cells

JW Hindley, DG Zheleva, Y Elani… - Proceedings of the …, 2019 - National Acad Sciences
… Using the sPLA 2 –M–MscL network to build a synthetic mechanosensitive signaling
pathway inside an artificial cell (AC). (A) Composition of the nested AC: A microscale POPC …

Chemically synthetic membrane receptors establish cells with artificial sense-and-respond signaling pathways

H Wu, L Zheng, N Ling, L Zheng, Y Du… - Journal of the …, 2023 - ACS Publications
… These results verified that our synthetic receptor was able to modulate specific cellular
a membrane-anchored synthetic receptor Ts-pHLIP-Pr for endowing cells with a new sense-and-…

A cascade signaling network between artificial cells switching activity of synthetic transmembrane channels

Q Yang, Z Guo, H Liu, R Peng, L Xu, C Bi… - Journal of the …, 2020 - ACS Publications
receptors, ligand-gated channels, and GPCRs to enhance the multifunctionality and authenticity
of artificial cell … turn leads to the development of artificial cells. However, few efforts have …