Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications

IP Trougakos, K Stamatelopoulos, E Terpos… - Journal of Biomedical …, 2021 - Springer
… Here we discuss SARS-CoV-2 life cycle and a number of approaches aiming to suppress …
collateral tissue damage that triggers the severe life-threatening complications of COVID-19. …

Viroporins: Structure, function, and their role in the life cycle of SARS-CoV-2

U Breitinger, NS Farag, H Sticht… - The international journal of …, 2022 - Elsevier
… When comparing the E protein of SARS CoV to that of SARS-CoVSARS CoV are exchanged
to serine and phenylalanine in CoV-2, while at position 69/70 glutamate and glycine in CoV

A novel cell culture system modeling the SARS-CoV-2 life cycle

X Ju, Y Zhu, Y Wang, J Li, J Zhang, M Gong… - PLoS …, 2021 - journals.plos.org
SARS-CoV-2 infection. Collectively, we developed a convenient and efficient SARS-CoV-2
reverse genetics tool to dissect the virus life … our understanding of SARS-CoV-2 biology and …

Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

R Poduri, G Joshi, G Jagadeesh - Cellular signalling, 2020 - Elsevier
… the SARS-CoV-2 virus life cycle in the host cell and provides a biological and pathological
point of view for repurposed and experimental drugs for this novel coronavirus. The viral life

The life cycle of SARS coronavirus in Vero E6 cells

Z Qinfen, C Jinming, H Xiaojun… - Journal of medical …, 2004 - Wiley Online Library
… the life cycle of severe acute respiratory syndrome-associated coronavirus (SARS CoV) in
… We propose a scheme of the life cycle of SARS coronavirus and discuss the mechanism of …

Immune life history, vaccination, and the dynamics of SARS-CoV-2 over the next 5 years

CM Saad-Roy, CE Wagner, RE Baker, SE Morris… - Science, 2020 - science.org
… Finally, we estimate the postpandemic immunity landscape and clinical case burden for
different possible futures (38) shaped by the various aspects of SARS-CoV-2 biology as well as …

The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …

W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
… However, many other SARS-CoV-2 proteins play an equally important role in the virus life
… Therefore, this paper focuses on the SARS-CoV-2 life cycle, the structure and function of N …

Cellular host factors for SARS-CoV-2 infection

J Baggen, E Vanstreels, S Jansen, D Daelemans - Nature Microbiology, 2021 - nature.com
… overview of proviral host factors for SARS-CoV-2. After explaining the coronavirus life cycle,
we discuss the cellular receptors and proteases that are required for SARS-CoV-2 entry. As …

Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge

B Raman, MP Cassar, EM Tunnicliffe, N Filippini… - …, 2021 - thelancet.com
… has comprehensively assessed multiple aspects of recovery in patients with SARS-CoV-2
infections including multiorgan magnetic resonance imaging, quality of life, exercise tolerance, …

The life of SARS-CoV-2 inside cells: Replication–transcription complex assembly and function

Z Lou, Z Rao - Annual Review of Biochemistry, 2022 - annualreviews.org
… Nonstructural proteins, also known as replicases, play essential roles in every aspect of
the life cycle of the virus inside the host cells ( Figure 1 ). After entry into the host cells, …