… nor has the cellular localization of the glucan synthase complex been investigated. … of the
glucan synthase complex of the filamentous fungus Aspergillus fumigatus, which is a human …

… –3 glucan synthesis may be active against Aspergillus but not … fumigatus and other fungi,
are glucan and chitin synthases … 6 glucan or the formation of the linkages between glucan and …

… α(1-3) glucan is a main component of the Aspergillus fumigatus cell wall. In spite of its
importance, synthesis of … fumigatus, AGS1 and AGS2, are highly homologous to the AGS genes of …

… fumigatus, α-(1,3)-glucan is a key component of the extracellular matrix, which … -glucan-chitin
fibrillar core. Interestingly, the deletion of the genes responsible for α-(1,3)-glucan synthesis …

1,3-β-Glucan synthase activity has been detected in a membrane fraction extracted from the
mycelium of the filamentous fungus Aspergillus fumigatus… 1,3-β-glucan synthase activity. The …

… fumigatus. In contrast to the glucan synthase, multiple genes have been found in the chitin
synthase and the alpha glucan synthase families; in spite of homologous sequences, each …

… Steps involved in the remodeling process are structural modifications of the linear glucan
chains, produced by the glucan synthase complex, followed by crosslinking of the different …

… morphology that these compounds produce in Aspergillus spp., it seemed likely … fumigatus
in vitro glucan synthesis. We have characterized an in vitro enzyme assay for glucan synthase …

… albicans glucan synthase activity. Hyphae were lysed in 50mM HEPES, pH 8.0, containing
… glucan synthase assays using both C. albicans and A. fumigatus extracts which can be used …

… New drugs are especially required in the case of treatment of aspergillosis because of the …
of invasive aspergillosis [4]. The recent clinical launch of Cancidas, ab (1,3)-glucan synthase …