Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism
B Witkowski, J Lelievre… - Antimicrobial agents …, 2010 - Am Soc Microbiol
… Flow cytometry analysis of strain F32-ART submitted to 9 μM artemisinin treatment. Yellow
dots (white gate) correspond to DAPI-positive events, and blue dots correspond to DAPI-…
dots (white gate) correspond to DAPI-positive events, and blue dots correspond to DAPI-…
[HTML][HTML] Induction of multidrug tolerance in Plasmodium falciparum by extended artemisinin pressure
S Ménard, TB Haddou, AP Ramadani… - Emerging infectious …, 2015 - ncbi.nlm.nih.gov
… Here, we report the susceptibility profile of F32-ART5 parasites selected after 5 years of
escalating artemisinin pressure and assess their susceptibility to this drug and other …
escalating artemisinin pressure and assess their susceptibility to this drug and other …
Induction of high tolerance to artemisinin by sub-lethal administration: A new in vitro model of P. falciparum
S De Lucia, I Tsamesidis, MC Pau, KR Kesely… - PLoS …, 2018 - journals.plos.org
… to assess a parasite tolerance to DHA or other antimalarial drug… life in patients in addition to
assessing parasite tolerance to a … , ARS1 possessed a higher tolerance to 700 nM DHA than …
assessing parasite tolerance to a … , ARS1 possessed a higher tolerance to 700 nM DHA than …
Assessment of artemisinin tolerance in Plasmodium falciparum clinical isolates in children with uncomplicated malaria in Ghana
SY Ahorhorlu, NB Quashie, RW Jensen, W Kudzi… - Malaria Journal, 2023 - Springer
… Continuous search for potential predictors of early onset of parasite tolerance to ART and
its … Thus, this study sought to assess and characterize correlates of potential ART tolerance …
its … Thus, this study sought to assess and characterize correlates of potential ART tolerance …
Phenotypic and Genotypic Analysis of In Vitro-Selected Artemisinin-Resistant Progeny of Plasmodium falciparum
… An alarming fact is that parasites in the field that are continually exposed to suboptimal
levels of artemisinin drugs may begin to tolerate high levels of these drugs, leading to a greater …
levels of artemisinin drugs may begin to tolerate high levels of these drugs, leading to a greater …
In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin
… This study reports an assessment of anti-malarial resistance marker polymorphisms in Pfmdr1,
Pfcrt, and … method of inducing resistance/tolerance to artemisinin in W2 and D6 lines of P. …
Pfcrt, and … method of inducing resistance/tolerance to artemisinin in W2 and D6 lines of P. …
Sustained Ex Vivo Susceptibility of Plasmodium falciparum to Artemisinin Derivatives but Increasing Tolerance to Artemisinin Combination Therapy Partner …
A Amambua-Ngwa, J Okebe, H Mbye… - Antimicrobial agents …, 2017 - Am Soc Microbiol
… ) was developed to assess parasites' susceptibility to artemisinin (9, 10). With increased
drug pressure from elimination interventions, they provide early indications of drug tolerance or …
drug pressure from elimination interventions, they provide early indications of drug tolerance or …
Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies
…, N Khim, S Sreng, P Chim, S Kim, P Lim… - The Lancet infectious …, 2013 - thelancet.com
… We aimed to assess whether an in-vitro ring-stage survival assay (RSA) can identify culture-…
We aimed to assess whether an in-vitro RSA can distinguish culture-adapted P falciparum …
We aimed to assess whether an in-vitro RSA can distinguish culture-adapted P falciparum …
Artemisinin resistance or tolerance in human malaria patients
J Krungkrai, W Imprasittichai, S Otjungreed… - Asian Pacific Journal of …, 2010 - Elsevier
… Having used transcriptome analysis in the falciparum … Increased tolerance to artemisinin
in Plasmodium falciparum … of resistance to artemisinin derivatives in Plasmodium falciparum. …
in Plasmodium falciparum … of resistance to artemisinin derivatives in Plasmodium falciparum. …
Artemisinin action and resistance in Plasmodium falciparum
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in …
in deaths resulting from Plasmodium falciparum malaria. Resistance to artemisinins, however, …
in deaths resulting from Plasmodium falciparum malaria. Resistance to artemisinins, however, …
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