… the events that govern early leukemogenesis in vivo. Adult T cell … A persistent oligo/polyclonal
expansion of HTLV-1-bearing … Here we review some of the consequences of HTLV-1 on its …

… The results of many studies led to the conclusion that Tax is the transforming protein in
HTLV-1-mediate leukemogenesis. Tax functions in a pleiotropic manner, including constitutive …

… in HTLV-1 research, and especially novel findings on viral transmission and leukemogenic
… associated with cellular transformation. Induction of hTERT by HBZ may be implicated in the …

… Recently, another HTLV-1 product, HBZ, which is encoded on … process of ATL leukemogenesis
by studying only HTLV-1, and … understanding of ATL leukemogenesis and new potential …

… HTLV-1 and its associated diseases, especially ATLL. The origin of the geographical distribution
of HTLV-1 … as a candidate cofactor for HTLV-1– induced leukemogenesis. Pulmonary …

… HTLV-1 and the distinct pathologies associated with HTLV-1 … to HTLV-1 infection, the strategies
used by HTLV-1 to subvert … plays a major role in leukemogenesis through deregulation of …

… and remaining enigmas in HTLV-I infection and its associated diseases, especially ATL. …
of HTLV-I and ATL research, with particular focus on the mechanism of leukemogenesis and …

… strategies to combat HTLV-1-associated diseases. … Tax and HBZ certainly contribute to
leukemogenesis in HTLV-1-… that HTLV-1 lacks a strong capacity to induce leukemogenesis, in …

… HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) [5, 6], HTLV-1-associated
uveitis [7], and HTLV-1-associated … the nature of leukemogenesis induced by HTLV-1. …

… infection leads to leukemia and HAM/TSP, whereas HTLV-2 is associated with only a few
cases of … to understand the multistep leukemogenic process associated with HTLV-1 infection. …