A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
… We performed an association scan of >500,000 SNPs in 280 … 873 controls replicated the
disease association of SNP A-1791411 in … Association was stronger in subjects with cholesterol …
disease association of SNP A-1791411 in … Association was stronger in subjects with cholesterol …
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25. 1
… nuclear factor kappa B to … associations we have identified relate to smoking behavior, which
in turn modulates lung cancer risk, rather than a direct effect of a genetic susceptibility factor …
in turn modulates lung cancer risk, rather than a direct effect of a genetic susceptibility factor …
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
, … Cancer Susceptibility Collaboration (UK)*, Stratton … - Nature …, 2007 - nature.com
… group to include individuals from the other disease groups, highlight notable new possibilities
for autoimmune regulation and suggest that IL23R may be a common susceptibility factor …
for autoimmune regulation and suggest that IL23R may be a common susceptibility factor …
Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans
… Genomic control was then used to adjust for potential inflated association … factor was
estimated to be 1.14 (see “Methods”). The distribution of P values adjusted for this inflation factor is …
estimated to be 1.14 (see “Methods”). The distribution of P values adjusted for this inflation factor is …
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
A Tenesa, SM Farrington, JGD Prendergast… - Nature …, 2008 - nature.com
… factors contribute to disease etiology, with about one-third of disease variance attributed to
inherited genetic factors 1 . … However, recent association studies have shown that common …
inherited genetic factors 1 . … However, recent association studies have shown that common …
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
BW Zanke, CMT Greenwood, J Rangrej, R Kustra… - Nature …, 2007 - nature.com
… cancer susceptibility. This is common genetic variant was identified by a genome-wide scan
using genetic association to successfully identify and validate a genetic risk factor for large …
using genetic association to successfully identify and validate a genetic risk factor for large …
Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes
… We identified genetic associations for susceptibility to diabetic nephropathy at two novel
candidate loci near the FRMD3 and CARS genes. Their identification implicates previously …
candidate loci near the FRMD3 and CARS genes. Their identification implicates previously …
A genome scan for joint‐specific hand osteoarthritis susceptibility: The Framingham Study
… that demonstrated a greater association in radiographic features of hand … factor pattern, in
our study an item was said to load on a given factor if the factor loading was ≥0.4 for that factor …
our study an item was said to load on a given factor if the factor loading was ≥0.4 for that factor …
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
… Thus, the ATG16L1 variant rs2241880 is a risk factor even in the absence of CARD15 …
confirming that rs2241880 allele G is a risk factor on a high-risk CARD15 genotype background as …
confirming that rs2241880 allele G is a risk factor on a high-risk CARD15 genotype background as …
[HTML][HTML] Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population
S Adachi, A Tajima, J Quan, K Haino… - Journal of human …, 2010 - nature.com
… This meta-analysis approach caused no marked under- or overdispersion of test statistics
for genetic association, because genomic inflation factor of 1.031 in combined data set was …
for genetic association, because genomic inflation factor of 1.031 in combined data set was …
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