… A Cochrane review examining the effectiveness of SAMAs in asthmatic children over the …
treatment of asthma in children were insufficient [Citation29]. In asthmatic adults SAMAs were …

… of improving the management of paediatric asthma, including the unmet need for … muscarinic
antagonist (LAMA) tiotropium as an add-on therapy for asthma management in children …

… promising results in adults, adolescents and children with asthma. Tiotropium Respimat has
recently been incorporated into the Global Initiative for Asthma 2015 treatment strategy as a …

… In particular the role of LABA in asthmatic children has come under close scrutiny by the
FDA given the paucity of evidence for their efficacy. Against this background of concern …

… A meta-analysis of 960 asthmatic children found that children with the homozygous Argine
(Arg)/Arg at position 16 of the ADRB2 demonstrated a favorable response to inhaled beta 2 …

… and, in line with this, tiotropium 5 μg add-on therapy has recently been approved in the EU
for use in children aged 6 years and older with symptomatic asthma [21]. Furthermore, the …

… studies with LAMAs in asthma have been in children, it might … to tiotropium in children aged
6–11 years with asthma is similar … or clearance of glycopyrrolate in children of different ages […

… ‘Should a long-acting inhaled muscarinic antagonist be used in adults and children with
severe asthma?’ was one of the fundamental questions included in the most recent document of …

… The extensive Phase II and III tiotropium clinical trial program has shown that this long-acting
muscarinic antagonist (LAMA) is well tolerated and efficacious as add-on therapy to …

… muscarinic antagonists are experiencing a rebirth of interest for the treatment of asthma [40]. …
-induced asthma [76] and in children with moderate to severe asthma exacerbations where …