The renin-angiotensin system in the brain: possible therapeutic implications for AT1-receptor blockers

J Culman, A Blume, P Gohlke, T Unger - Journal of human hypertension, 2002 - nature.com
… Blockade of brain and cerebrovascular AT 1 receptors by AT 1 receptor blockers prevents …
its receptors in the brain, and discusses the possible consequences of AT 1 receptor blockade …

The renin-angiotensin system and its receptors

U Stroth, T Unger - Journal of cardiovascular pharmacology, 1999 - journals.lww.com
AT 1 receptors, whereas AT 2 receptor expression is limited (39,70,71) . Stimulation of AT 1
receptors … All these effects are mediated by AT 1 receptors in periventricular organs and the …

A century old renin–angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology

P Balakumar, G Jagadeesh - Cellular signalling, 2014 - Elsevier
… The AT 1 receptor plays an important role in the physiology and pathology of the … by the
increased therapeutic use of AT 1 receptor blockers, ACE inhibitors, and a renin inhibitor for the …

The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes

RL Davisson, G Yang, TG Beltz, MD Cassell… - Circulation …, 1998 - Am Heart Assoc
… 18 Activation of AT-1 receptors in both intrinsic brain regions … both the human renin (HREN)
and human angiotensinogen (… examined the role of central AT-1 receptors, as well as the …

… demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II–renin feedback …

M Azizi, J Menard, A Bissery, TT Guyenne… - Journal of the …, 2004 - journals.lww.com
renin release or “renin/pharmacokinetic index” (RPI), expressed in pg active … , renin
and AT1 receptors. They have shown that the interruption of the RAS at the level of the Ang II–renin

Evidence for activation of the renin–angiotensin system in the human prostate: increased angiotensin II and reduced AT1 receptor expression in benign prostatic …

DT Dinh, AG Frauman, GR Somers… - The Journal of …, 2002 - Wiley Online Library
AT 1 receptor proteins were examined in the normal human … of the epithelium and AT 1
receptor immunostaining was found … However, AT 1 receptor immunoreactivity was significantly …

The CNS renin-angiotensin system

O Von Bohlen und Halbach, D Albrecht - Cell and tissue research, 2006 - Springer
… Neuronal AT1 receptors mediate the stimulatory actions of Ang II on blood … AT2 receptors
have been implicated in the stimulation of apoptosis and as being antagonistic to AT1 receptors

Angiotensin AT1/AT2 receptors: regulation, signalling and function

E Kaschina, T Unger - Blood pressure, 2003 - Taylor & Francis
… in AT1/AT2 receptor research during the last few years. AT1 RECEPTORS The AT1 receptor
… By inhibiting the AT1 receptor-mediated negative feedback of Ang II on renin release in the …

Renin‐angiotensin system revisited

F Fyhrquist, O Saijonmaa - Journal of internal medicine, 2008 - Wiley Online Library
… The recent discovery of renin receptors has made our view of RAS unexpectedly complex …
and AT1 receptor blockers. Great expectations are now generated by the introduction of renin

AT1 receptor-mediated enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats

MC Prieto-Carrasquero, H Kobori… - American Journal …, 2005 - journals.physiology.org
… tubular renin in ANG II-dependent hypertension is mediated by an AT 1 receptor mechanism…
, a specific AT 1 receptor blocker. The data demonstrate that the increases in distal nephron …