… using full-length ataxin-3 constructs. We demonstrate in vivo that nuclear localization of
ataxin-3 is required for the generation of symptoms and that export of ataxin-3 out of the nucleus …

… required for nuclear localization of the Josephin domain and regulated nuclear localization
of … Importantly, we found that oxidative stress also induced nuclear localization of Atx3; both …

… A putative nuclear localization signal (NLS) (RKRR) is … is involved in the ataxin-3 nuclear
localization found in the Hela … the nuclear ataxin-3 is associated with the inner nuclear matrix …

… localization of ataxin-3 for the pathogenesis of SCA3 in vivo using transgenic mouse models.
We showed that nuclear localization of ataxin-3 … and that cytoplasmic ataxin-3 was not able …

… or nuclear localization signal. Moreover, fragment 1 from AT-Q72 (27-FSPVE) was found
to be located in all cell compartments analyzed: (cytoplasm, nucleus, membranes, and …

… is associated with the inner nuclear matrix. Our results taken together with the finding of a
nuclear localization signal in ataxin-3 indicate that the ataxin-3 protein per se translocates to …

… nuclear localization, aggregation and stability of ataxin-3 (ATXN3), the disease protein in
spinocerebellar ataxia type 3 (… were particularly important for nuclear localization of normal and …

… proteolysis by calpains is required for nuclear localization of mutant ataxin 3; (ii) inhibition of
… ; (iii) production of mutant ataxin 3 cleavage fragments and the resulting nuclear localization …

… truncated and full-length expanded ataxin-3, rescue neurodegeneration, restore photoreceptor
… nuclear localization signals (NLSs), this work unites ataxin-3 structure to the nuclear pore …

… Since pathological Atx3 aggregates in the nucleus of affected neurons in MJD, and there
is in vivo evidence that nuclear localization of Atx3 is required for the manifestation of …