… by select proteotoxic stresses (… proteotoxic stressors alter Atx3 interactions with VCP and
hHR23B. In the early phase of this study, we found that heat shock, a general proteotoxic stress, …

… In chapter II of this thesis I show that proteotoxic stresses (heat shock and oxidative stress)
increase nuclear localization of Atx3 and also show that serine-111 and the C-terminal …

… Although many of the molecular pathways regulating proteotoxic stress and longevity are …
cord and sensory neuron susceptibility to mutant ataxin-3 that was distinct from the aggregation …

… Recent work in our lab demonstrated that Atxn3 responded to select proteotoxic stresses by
altering its interactions with two shuttle proteins that function in protein degradation, valosin-…

… phenotype of atx-3 nulls is that the absence of ataxin-3 at some timepoint of the development
causes cellular (proteotoxic?) stress, which activates the stress machinery, and once they …

… proteotoxic stress and transcriptional dysregulation [21–23]. Consequently, this investigation
is aimed at clarifying the mechanisms underlying AT3 aggregation and how the different …

… “Identification of modulators of ataxin-3 proteotoxicity in animal models of … knock-out has
no major influence in mutant ataxin-3-mediated pathogenesis. These findings contradict the …

… Heat shock, a general proteotoxic stress, also induces wild-type and pathogenic AT-… bind
ataxin-3. Interestingly, the inhibitory effect of ADP was lost when N-terminally truncated ataxin3 …

… polyQ-induced ataxin-1 misfolding and proteotoxicity in cell … of coiled-coil (CC) domains in
ataxin-1 toxicity enhancers, while such … We found that the ataxin-1–interacting protein MED15, …

… 3 (SCA3), which are caused by expanded forms of ataxin-2 (ATXN2) and … stress responses,
and an inability to keep up with cellular stress (in particular, proteotoxic and oxidative stress) …