Mitochondrial aldehyde dehydrogenase activation by Alda‐1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E‐knockout mice
A Stachowicz, R Olszanecki, M Suski… - Journal of the …, 2014 - Am Heart Assoc
… development of atherosclerosis and nonalcoholic fatty liver disease ( NAFLD ). … aldehyde
dehydrogenase ( ALDH 2), an enzyme responsible for the detoxification of reactive aldehydes, …
dehydrogenase ( ALDH 2), an enzyme responsible for the detoxification of reactive aldehydes, …
[HTML][HTML] Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic plaque
C Pan, J Xing, C Zhang, Y Zhang, L Zhang, S Wei… - Oncotarget, 2016 - ncbi.nlm.nih.gov
… Our data here for the first time provide convincing evidence that ALDH2 can influence
atherosclerotic plaque development and vulnerability, and inflammatory response via the MAPK, …
atherosclerotic plaque development and vulnerability, and inflammatory response via the MAPK, …
[HTML][HTML] Aldehyde dehydrogenase 2 deficiency promotes atherosclerotic plaque instability through accelerating mitochondrial ROS-mediated vascular smooth muscle …
H Zhu, Z Wang, Z Dong, C Wang, Q Cao, F Fan… - … et Biophysica Acta (BBA …, 2019 - Elsevier
… role for aldehyde dehydrogenase 2 (ALDH2) in suppressing atherosclerotic plaque progression
… -cholesterol diet-induced atherosclerotic plaque progression and plaque vulnerability in …
… -cholesterol diet-induced atherosclerotic plaque progression and plaque vulnerability in …
The role of aldehyde dehydrogenase 2 in cardiovascular disease
J Zhang, Y Guo, X Zhao, J Pang, C Pan… - Nature Reviews …, 2023 - nature.com
… In this Review, we describe the latest findings on the enzymatic and non-enzymatic roles
of ALDH2 in the development of CVD such as atherosclerosis, coronary artery disease, …
of ALDH2 in the development of CVD such as atherosclerosis, coronary artery disease, …
Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells
M Yang, Y Wang, B Han, B Yang, Y Qiang… - Acta Pharmacologica …, 2018 - nature.com
… A wide variety of factors have been identified to contribute to the development of atherosclerosis,
including the following: injury to endothelial cells 1 , abnormal proliferation, migration …
including the following: injury to endothelial cells 1 , abnormal proliferation, migration …
Macrophage ALDH2 (aldehyde dehydrogenase 2) stabilizing Rac2 is required for efferocytosis internalization and reduction of atherosclerosis development
J Zhang, X Zhao, Y Guo, Z Liu, S Wei… - … and Vascular Biology, 2022 - Am Heart Assoc
… for the development and poor prognosis of atherosclerotic cardiovascular … atherosclerosis,
and enhancement of arterial macrophage efferocytosis reduces atherosclerosis development…
and enhancement of arterial macrophage efferocytosis reduces atherosclerosis development…
Reactive aldehyde-scavenging enzyme activities in atherosclerotic plaques of cigarette smokers and nonsmokers
D Lapenna, G Ciofani, S Ucchino, MA Giamberardino… - Atherosclerosis, 2015 - Elsevier
… In particular, aldehyde dehydrogenase (ALDH) can catalyze the pyridine nucleotide-dependent …
Cigarette smoking is a well-known risk factor for the development of atherosclerosis and …
Cigarette smoking is a well-known risk factor for the development of atherosclerosis and …
The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease
F Xu, Y Sun, R Shang, M Li, L Cui, Z Cui… - The Tohoku journal of …, 2014 - jstage.jst.go.jp
… reflect the degree of vascular atherosclerotic plaque burden. Therefore, the … atherosclerosis.
Consequently, the impact of ALDH2 on the occurrence and development of atherosclerosis …
Consequently, the impact of ALDH2 on the occurrence and development of atherosclerosis …
Effects of aldehyde dehydrogenase genotypes on carotid atherosclerosis
M Narita, K Kitagawa, Y Nagai, H Hougaku… - Ultrasound in medicine …, 2003 - Elsevier
… m aldehyde dehydrogenase (ALDH2), a key enzyme in alcohol metabolism, which potentially
modifies the prevalence of atherosclerosis. … ”) and carotid atherosclerosis in 304 Japanese …
modifies the prevalence of atherosclerosis. … ”) and carotid atherosclerosis in 304 Japanese …
Aldehyde dehydrogenase 2 protects against abdominal aortic aneurysm formation by reducing reactive oxygen species, vascular inflammation, and apoptosis of …
SH Tsai, LA Hsu, HY Tsai, YH Yeh, CY Lu… - The FASEB …, 2020 - Wiley Online Library
… We concluded that ALDH2 deficiency is associated with the development of AAAs in humans
… Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic …
… Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic …
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