Disturbed flow-enhanced endothelial turnover in atherosclerosis

Q Xu - Trends in cardiovascular medicine, 2009 - Elsevier
… in these areas related to altered blood flow involve different signal pathways, for … disturbed
flow and to discuss the underlining mechanisms in the development of atherosclerosis

Development of femoral atherosclerosis in relation to flow disturbances

Ö Smedby, S Nilsson, L Bergstrand - Journal of biomechanics, 1996 - Elsevier
flow disturbances in oiuo and correlate them to the subsequent development of atherosclerosis
The primary hypothesis underlying this study is that disturbed flow-either flow separation …

Intravascular hemodynamic factors responsible for progression of coronary atherosclerosis and development of vulnerable plaque

CL Feldman, PH Stone - Current opinion in cardiology, 2000 - journals.lww.com
… This fibrous plaque will cause a further disturbance of the downstream blood flow pattern, …
This disturbed flow, in turn, will lead to further progression of atherosclerosis. The culmination …

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

L Zeng, A Zampetaki, A Margariti… - Proceedings of the …, 2009 - National Acad Sciences
… stress is reported to be involved in atherosclerosis (18–22), … disturbed flow induces XBP1
splicing and sustained activation that led to EC apoptosis and the formation of atherosclerotic

Specific Induction of tie1 Promoter by Disturbed Flow in Atherosclerosis-Prone Vascular Niches and Flow-Obstructing Pathologies

RM Porat, M Grunewald, A Globerman, A Itin… - Circulation …, 2004 - Am Heart Assoc
… exposed to disturbed flow, ie, the areas prone to develop atherosclerosis. Moreover, we …
of pathological flow obstructions, including by the protrusion of atherosclerotic lesions into the …

Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives

JJ Chiu, S Chien - Physiological reviews, 2011 - journals.physiology.org
… protective against atherosclerosis, whereas disturbed flow with associated … disturbed flow
pattern in branch points and curvatures causes the preferential localization of atherosclerotic

Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species

MC Gage, NY Yuldasheva, H Viswambharan… - Atherosclerosis, 2013 - Elsevier
atherosclerosis development in areas with disturbed flow patterns such as the aortic sinus
and the lesser curvature of the aorta. Moreover, we have demonstrated at the mechanistic …

Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow

A Zampetaki, L Zeng, A Margariti, Q Xiao, H Li… - Circulation, 2010 - Am Heart Assoc
… in HDAC3 stabilization in response to disturbed flow, we treated endothelial cells with various
inhibitors before the initiation of flow. Cells were exposed to disturbed flow for 4 hours. As …

Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis

K Van der Heiden, BP Hierck, R Krams, R de Crom… - Atherosclerosis, 2008 - Elsevier
… is reminiscent of the atherosclerotic predilection sites. Thus, we … atherosclerotic predilection
sites, where flow is disturbed, in wild type mice and they occur on and around atherosclerotic

Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis

D Nam, CW Ni, A Rezvan, J Suo… - American Journal …, 2009 - journals.physiology.org
… Here, we report that partial ligation causes disturbed flow, induces atherosclerosis rapidly
within 2 wk upon feeding a high-fat diet, and that the additional simple RNA isolation method …