Disturbed flow-enhanced endothelial turnover in atherosclerosis
Q Xu - Trends in cardiovascular medicine, 2009 - Elsevier
… in these areas related to altered blood flow involve different signal pathways, for … disturbed
flow and to discuss the underlining mechanisms in the development of atherosclerosis…
flow and to discuss the underlining mechanisms in the development of atherosclerosis…
Development of femoral atherosclerosis in relation to flow disturbances
Ö Smedby, S Nilsson, L Bergstrand - Journal of biomechanics, 1996 - Elsevier
… flow disturbances in oiuo and correlate them to the subsequent development of atherosclerosis…
The primary hypothesis underlying this study is that disturbed flow-either flow separation …
The primary hypothesis underlying this study is that disturbed flow-either flow separation …
Intravascular hemodynamic factors responsible for progression of coronary atherosclerosis and development of vulnerable plaque
CL Feldman, PH Stone - Current opinion in cardiology, 2000 - journals.lww.com
… This fibrous plaque will cause a further disturbance of the downstream blood flow pattern, …
This disturbed flow, in turn, will lead to further progression of atherosclerosis. The culmination …
This disturbed flow, in turn, will lead to further progression of atherosclerosis. The culmination …
Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow
L Zeng, A Zampetaki, A Margariti… - Proceedings of the …, 2009 - National Acad Sciences
… stress is reported to be involved in atherosclerosis (18–22), … disturbed flow induces XBP1
splicing and sustained activation that led to EC apoptosis and the formation of atherosclerotic …
splicing and sustained activation that led to EC apoptosis and the formation of atherosclerotic …
Specific Induction of tie1 Promoter by Disturbed Flow in Atherosclerosis-Prone Vascular Niches and Flow-Obstructing Pathologies
RM Porat, M Grunewald, A Globerman, A Itin… - Circulation …, 2004 - Am Heart Assoc
… exposed to disturbed flow, ie, the areas prone to develop atherosclerosis. Moreover, we …
of pathological flow obstructions, including by the protrusion of atherosclerotic lesions into the …
of pathological flow obstructions, including by the protrusion of atherosclerotic lesions into the …
Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives
JJ Chiu, S Chien - Physiological reviews, 2011 - journals.physiology.org
… protective against atherosclerosis, whereas disturbed flow with associated … disturbed flow
pattern in branch points and curvatures causes the preferential localization of atherosclerotic …
pattern in branch points and curvatures causes the preferential localization of atherosclerotic …
Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species
… atherosclerosis development in areas with disturbed flow patterns such as the aortic sinus
and the lesser curvature of the aorta. Moreover, we have demonstrated at the mechanistic …
and the lesser curvature of the aorta. Moreover, we have demonstrated at the mechanistic …
Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow
A Zampetaki, L Zeng, A Margariti, Q Xiao, H Li… - Circulation, 2010 - Am Heart Assoc
… in HDAC3 stabilization in response to disturbed flow, we treated endothelial cells with various
inhibitors before the initiation of flow. Cells were exposed to disturbed flow for 4 hours. As …
inhibitors before the initiation of flow. Cells were exposed to disturbed flow for 4 hours. As …
Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis
… is reminiscent of the atherosclerotic predilection sites. Thus, we … atherosclerotic predilection
sites, where flow is disturbed, in wild type mice and they occur on and around atherosclerotic …
sites, where flow is disturbed, in wild type mice and they occur on and around atherosclerotic …
Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis
D Nam, CW Ni, A Rezvan, J Suo… - American Journal …, 2009 - journals.physiology.org
… Here, we report that partial ligation causes disturbed flow, induces atherosclerosis rapidly
within 2 wk upon feeding a high-fat diet, and that the additional simple RNA isolation method …
within 2 wk upon feeding a high-fat diet, and that the additional simple RNA isolation method …
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