… Th1 and Th2 cytokine-associated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitis

S Arakawa, Y Hatano, K Katagiri - Clinical & Experimental …, 2004 - academic.oup.com
… of these factors in vivo in atopic dermatitis, the role of each … and for cytokines in PBMC from
patients with atopic dermatitis. We … in the pathogenesis of atopic dermatitis, with or without a …

Overexpression of the suppressor of cytokine signalling 3 (SOCS3) in severe atopic dermatitis

Y Horiuchi, SJ Bae, I Katayama - Clinical and experimental …, 2006 - academic.oup.com
… in allergic conditions has now shifted to the role of signal downregulation through suppressors
of cytokine … may serve to maintain balance among cytokines regulating the Th1‐ and Th2‐…

Cytokine and anti-cytokine therapies for psoriasis and atopic dermatitis

RP Numerof, K Asadullah - BioDrugs, 2006 - Springer
cytokines or groups of cytokines, either through suppression or enhancement, have given
clinicians additional options for the treatment of patients with psoriasis or atopic dermatitis. The …

Immune dysregulation in atopic dermatitis

PY Ong, DMY Leung - Current allergy and asthma reports, 2006 - Springer
… Possible mechanisms include increased Th1 cell apoptosis or an increased expression of
suppressor of cytokine signaling-3 (SOCS-3), which inhibits Th1 cell differentiation, skewing …

Suppressor of cytokine signaling in allergic inflammation

J Knisz, PB Rothman - Journal of allergy and clinical immunology, 2007 - Elsevier
… The magnitude and the duration of cytokine action will determine the response to an …
reaction such as asthma or atopic dermatitis. Thus, the action of cytokines is tightly regulated both …

Atopic dermatitis and cytokines: recent patents in immunoregulatory and therapeutic implications of cytokines in atopic dermatitis-part I: cytokines in atopic dermatitis

JH Lee, G Noh, S Lee, YS Youn… - Recent patents on …, 2012 - ingentaconnect.com
Atopic dermatitis is a chronic allergic inflammatory disease of the skin. Its pathophysiology
involves an orchestrated sequence of allergicAtopic dermatitis is described under the …

Serum cytokine levels in atopic dermatitis

Y Yoshizawa, H Nomaguchi, S Izaki… - Clinical and …, 2002 - academic.oup.com
… with atopic dermatitis (AD) may reflect increased responses of type 2 T‐helper (Th2) cytokines
… Therefore, we investigated serum levels of several cytokines [interleukin (IL)‐18, IL‐12, IL‐…

Absence of T-regulatory cell expression and function in atopic dermatitis skin

J Verhagen, M Akdis, C Traidl-Hoffmann… - Journal of allergy and …, 2006 - Elsevier
… , IL-10 and TGF-β, as well as receptors for these cytokines … in lesional and atopy patch test
atopic dermatitis or psoriasis skin. … effector cytokines such as TNF-α and IFN-γ and suppressor

Inflammatory Skin Diseases: Focus on the Role of Suppressors of Cytokine Signaling (SOCS) Proteins

A Cianciulli, R Calvello, C Porro, DD Lofrumento… - Cells, 2024 - mdpi.com
… Psoriasis (PS) and atopic dermatitis (AD) are the most common … Suppressor of cytokine
signaling (SOCS) proteins are … pathways activated by proinflammatory cytokines. SOCS signaling …

The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis

A Otsuka, T Nomura, P Rerknimitr… - Immunological …, 2017 - Wiley Online Library
… does not ameliorate AD-like dermatitis because the cytokine environment changes from a
Th1/… include both the suppression of proinflammatory cytokines, and the induction of inhibitory …