… We provide a genome-wide catalog of the genetic control of gene expression in human left
atrial … to identify the genes and genetic variants responsible for complex diseases such as AF. …

… The genes encoding the major currents of the atrial action … Mutation in this gene associated
with atrial fibrillation. … GWAS to evaluate genetic determinants of rate-control therapy. Patients …

… Two years later, the first GWAS meta-analysis from the international Atrial Fibrillation Genetics
(AFGen) Consortium, including ~6,500 AF cases, revealed six new genetic loci for AF (28). …

… Atrial fibrillation (AF) is the most common cardiac arrhythmia and is characterized by rapid
and disorganized electrical activation of the atria, leading to uncoordinated contraction. The …

… The target genes controlled by these regulatory elements may be in close proximity, or
located more distally on the same chromosome (cis) or on another chromosome (trans). Some …

… More than 30 million people around the world were affected by atrial fibrillation (AF) in 2010.
The lifetime risk of developing AF in people of European descent older than 40 years one in …

… The largest to date was recently led by our group and others in the Atrial Fibrillation Genetics
Consortium or AFGen, and included about 18 000 individuals with AF and over 1 00 000 …

… atrial fibrillation. Our findings suggest possible genetic control on the pathogenesis of atrial
fibrillation… Atrial fibrillation is the most common type of sustained tachyarrhythmia in humans1, …

… Also, in AF in the setting of underlying diseases, it is suggested that some form of genetic
control may be present. Understanding the molecular mechanisms underlying AF may provide …

… The genes and genetic loci found to be associated with atrial fibrillation can roughly be
grouped according to three main biological pathways: variants influencing cardiogenesis, cell …