… These transcription factors target thousands of regulatory elements for genes involved in
atrial function, including ion channels, gap junctions, structural/cytoskeletal components, and …

Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart
failure, and premature death. The pathogenesis of AF remains poorly understood, which …

… regulatory elements and target gene expression. To uncover causal genetic variants, variant
regulatory elements and … Of 104 genetic variant regions associated with atrial fibrillation …

… F, Top 10 motifs found in STARR-seq between −1.5 and 1.5 L2FC that we consider not to
be potential regulatory elements. A–F, HOMER calculates Q values using the Benjamini-…

… are presumed to contain regulatory sequences that influence gene … elements and to define
function-altering “business” SNPs. The target genes controlled by these regulatory elements …

… To identify putative cis-regulatory elements located in the 4q25 … of histone modifications
associated with active elements [23] (… Overall, our results suggest that the regulatory elements …

… We used MACS2 to identify peak regions (P<0.01), applied a Markov model to classify
regulatory elements, and annotated this model with matched gene expression data. We …

… In summary, the miRNAs exert their specific regulatory functions affecting the stability or
translation of targeted mRNA. Importantly, they have been described to partake in numerous …

… Atrial fibrillation (AF) is the most common clinical arrhythmia and is associated with cardiovascular
morbidity and excessive mortality [1, 2]. AF can occur in patients without evident heart …

… Atrial fibrillation (AF), the most common cardiac arrhythmia, is characterized by absence of P
… Furthermore, studies showed that PITX2c also down-regulated the expression of Nppa and …