Novel molecular targets for atrial fibrillation therapy
… fibrillation, and several new compounds are under development. This Review focuses on …
of new anti-atrial fibrillation drugs, on the molecular and structural motifs that they target and on …
of new anti-atrial fibrillation drugs, on the molecular and structural motifs that they target and on …
Oxidative stress and inflammation in atrial fibrillation: role in pathogenesis and potential as a therapeutic target
DR Van Wagoner - Journal of cardiovascular pharmacology, 2008 - journals.lww.com
Atrial fibrillation (AF) is one of the most prevalent and vexing cardiovascular conditions.
Available treatments for AF based on ion channel blockade are only poorly effective. The …
Available treatments for AF based on ion channel blockade are only poorly effective. The …
A new therapeutic framework for atrial fibrillation drug development
YS Ang, S Rajamani, SM Haldar, J Hueser - Circulation research, 2020 - Am Heart Assoc
… myopathy provides many new opportunities for detailed understanding of underlying
mechanisms and can guide identification of therapeutic targets that extend well beyond the …
mechanisms and can guide identification of therapeutic targets that extend well beyond the …
Atrial fibrillation: hypertension as a causative agent, risk factor for complications, and potential therapeutic target
JS Healey, SJ Connolly - The American journal of cardiology, 2003 - Elsevier
… , left atrial enlargement, and slowing of atrial conduction velocity. … of atrial fibrillation, and
they increase the risk of thromboembolic complications. Conventional therapy of atrial fibrillation …
they increase the risk of thromboembolic complications. Conventional therapy of atrial fibrillation …
EZH2 as a novel therapeutic target for atrial fibrosis and atrial fibrillation
S Song, R Zhang, B Mo, L Chen, L Liu, Y Yu… - Journal of molecular and …, 2019 - Elsevier
… and atrial fibrosis and AF. Next, we further validated the relationship between EZH2 and
atrial fibrillation using two atrial fibrosis animal models. Mice developed significant atrial fibrosis …
atrial fibrillation using two atrial fibrosis animal models. Mice developed significant atrial fibrosis …
Atrial fibrillation burden: a new outcome predictor and therapeutic target
N Becher, A Metzner, T Toennis, P Kirchhof… - European Heart …, 2024 - academic.oup.com
… The estimated risk of stroke associated with atrial fibrillation burden or atrial fibrillation …
median atrial fibrillation burden of 0.13% (interquartile range 0.03–1.05). Atrial fibrillation burden …
median atrial fibrillation burden of 0.13% (interquartile range 0.03–1.05). Atrial fibrillation burden …
Role of tumor necrosis factor alpha in the pathogenesis of atrial fibrillation: a novel potential therapeutic target?
M Ren, X Li, L Hao, J Zhong - Annals of medicine, 2015 - Taylor & Francis
… the related mechanisms, and exploits its potential usefulness as a novel therapeutic target.
… be a good prognostic biomarker and novel potential therapeutic target for atrial fibrillation. …
… be a good prognostic biomarker and novel potential therapeutic target for atrial fibrillation. …
Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target
… Our purpose is to highlight a shared mechanism linking HF and AF that is also a
therapeutic target: diastolic Ca 2+ leak from the sarcoplasmic reticulum (SR) via RYR2. …
therapeutic target: diastolic Ca 2+ leak from the sarcoplasmic reticulum (SR) via RYR2. …
Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke
R Zou, D Zhang, L Lv, W Shi, Z Song, B Yi, B Lai… - Journal of translational …, 2019 - Springer
… Atrial fibrillation (AF) is one of the most prevalent sustained arrhythmias, however, … between
atrial fibrillation (AF) and stroke and reveal potential biomarkers and therapeutic targets of AF…
atrial fibrillation (AF) and stroke and reveal potential biomarkers and therapeutic targets of AF…
… into the role of the autonomic nervous system in the creation of substrate for atrial fibrillation: implications for therapies targeting the atrial autonomic nervous system
R Arora - Circulation: Arrhythmia and Electrophysiology, 2012 - Am Heart Assoc
… approaches targeting the autonomic innervation of the atria, we also describe recent biological
(gene therapy) attempts to selectively disrupt parasympathetic signaling in the atria using …
(gene therapy) attempts to selectively disrupt parasympathetic signaling in the atria using …
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