… fibrillation, and several new compounds are under development. This Review focuses on …
of new anti-atrial fibrillation drugs, on the molecular and structural motifs that they target and on …

Atrial fibrillation (AF) is one of the most prevalent and vexing cardiovascular conditions.
Available treatments for AF based on ion channel blockade are only poorly effective. The …

… myopathy provides many new opportunities for detailed understanding of underlying
mechanisms and can guide identification of therapeutic targets that extend well beyond the …

… , left atrial enlargement, and slowing of atrial conduction velocity. … of atrial fibrillation, and
they increase the risk of thromboembolic complications. Conventional therapy of atrial fibrillation …

… and atrial fibrosis and AF. Next, we further validated the relationship between EZH2 and
atrial fibrillation using two atrial fibrosis animal models. Mice developed significant atrial fibrosis …

… The estimated risk of stroke associated with atrial fibrillation burden or atrial fibrillation …
median atrial fibrillation burden of 0.13% (interquartile range 0.03–1.05). Atrial fibrillation burden …

… the related mechanisms, and exploits its potential usefulness as a novel therapeutic target.
… be a good prognostic biomarker and novel potential therapeutic target for atrial fibrillation. …

… Our purpose is to highlight a shared mechanism linking HF and AF that is also a
therapeutic target: diastolic Ca 2+ leak from the sarcoplasmic reticulum (SR) via RYR2. …

… Atrial fibrillation (AF) is one of the most prevalent sustained arrhythmias, however, … between
atrial fibrillation (AF) and stroke and reveal potential biomarkers and therapeutic targets of AF…

… approaches targeting the autonomic innervation of the atria, we also describe recent biological
(gene therapy) attempts to selectively disrupt parasympathetic signaling in the atria using …