A risk score for type 1 diabetes derived from autoantibody-positive participants in the Diabetes Prevention Trial–Type 1

…, Diabetes Prevention Trial–Type 1 Study Group - Diabetes …, 2008 - Am Diabetes Assoc
… OBJECTIVE—The accurate prediction of type 1 diabetes is … developed a risk score for the
prediction of type 1 diabetes. … in the risk score was in itself predictive of type 1 diabetes. There …

The prediction of type 1 diabetes by multiple autoantibody levels and their incorporation into an autoantibody risk score in relatives of type 1 diabetic patients

…, Type 1 Diabetes TrialNet and the Diabetes … - Diabetes …, 2013 - Am Diabetes Assoc
… effect of autoantibody levels on prediction accuracy, we developed a risk score based on
positivity or negativity alone (without levels) of the five autoantibodies. In the absence of …

A type 1 diabetes genetic risk score predicts progression of islet autoimmunity and development of type 1 diabetes in individuals at risk

MJ Redondo, S Geyer, AK Steck, S Sharp… - Diabetes …, 2018 - Am Diabetes Assoc
… from single to multiple autoantibodies, we also adjusted for autoantibody type (ie, GAD65, …
for DPT-1 Risk Score and the number of positive autoantibodies present at screening. T1D …

A type 1 diabetes genetic risk score can identify patients with GAD65 autoantibody–positive type 2 diabetes who rapidly progress to insulin therapy

AL Grubb, TJ McDonald, F Rutters, LA Donnelly… - Diabetes …, 2019 - Am Diabetes Assoc
… in clinically diagnosed type 2 diabetes is highly variable. GAD65 autoantibodies (GADA) are
… We aimed to determine if a type 1 diabetes genetic risk score (T1D GRS) could predict rapid …

Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study

M Ghalwash, V Anand, O Lou, F Martin… - The Lancet Child & …, 2023 - thelancet.com
… whether islet autoantibody screening is effective for predicting type 1 diabetes in adolescents
… A combined risk score enhances prediction of type 1 diabetes among susceptible children. …

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: a prospective study in children

E Bonifacio, A Beyerlein, M Hippich, C Winkler… - PLoS …, 2018 - journals.plos.org
… to work on genetic risk scores in Type 1 diabetes). RAO has a UK Medical Research Council
confidence in concept grant to turn a type 1 diabetes genetic risk score into a diagnostic test …

The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening

LM Jacobsen, L Bocchino, C Evans-Molina, L DiMeglio… - Diabetologia, 2020 - Springer
risk of type 1 diabetes compared with other autoantibody pairs. In addition, we further assessed
type 1 diabetes risk in all autoantibody … implications for autoantibody combinations can …

The relationship between islet autoantibody status and the genetic risk of type 1 diabetes in adult-onset type 1 diabetes

NJ Thomas, HC Walkey, A Kaur, S Misra, NS Oliver… - Diabetologia, 2023 - Springer
… We compared the overall type 1 diabetes genetic risk score (… -positive individuals or
autoantibody-negative and -positive … risk of type 1 diabetes based on 30 known type 1 diabetes-…

A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes

MB Johnson, KA Patel, E De Franco, JAL Houghton… - Diabetologia, 2018 - Springer
… due to shared polygenic risk and islet- and other organ-specific autoantibodies are present
in … a type 1 diabetes genetic risk score (GRS) could identify monogenic autoimmune diabetes

Autoantibody reversion: changing risk categories in multiple-autoantibody–positive individuals

M So, C O'Rourke, HT Bahnson, CJ Greenbaum… - Diabetes …, 2020 - Am Diabetes Assoc
… islet autoantibodies progress to clinical type 1 diabetes. … incidence of type 1 diabetes diagnosis
by autoantibody maintenance … of type 1 diabetes diagnosis by autoantibody maintenance …