… adequate response to TNF-targeted therapy. However, the ready availability of anakinra
allowed for proof-of-concept trials in many of the autoinflammatory diseases, where it has had a …

… for these diseases. Throughout the paper, I will reflect on gaps in knowledge of autoinflammatory
diseases and will highlight the latest advances and newest drugs in development. …

… autoinflammatory diseases have resulted in effective therapies targeting proinflammatory …
IL-1 β and TNF and uncovered other new potential targets for anti-inflammatory therapies. …

… They are classified along the spectrum as autoinflammatory disease, polygenic
autoinflammatory conditions, mixed pattern diseases or polygenic autoimmune conditions, and …

… counterpart SJIA and monogenic autoinflammatory diseases, there is growing evidence
that AOSD is an autoinflammatory disorder based on its laboratory and clinical manifestations. …

… targets whereby clinical trials are ongoing and briefly discuss some of the newly emerging
molecules targeting … give a brief overview of other autoinflammatory diseases in which NLRP3 …

… been expanded to include other monogenic autoinflammatory diseases that result in IL-1-…
by clinical response to IL-1-targeted therapies. The monogenic disorders are generally rare, …

… Further, we searched on ‘autoinflammatory diseases’ and synonyms, and manually checked
references of relevant original studies and reviews for missing articles. For more details on …

… multifactorial autoinflammatory diseases, and the common dermatologic conditions in which
… has contributed to a growing arsenal of targeted therapies, not only drastically improving …

… -mediated autoinflammatory diseases, are broadening the concept which we consider to be
autoinflammatory … Such rapid and profound responses to a very targeted therapy implies that …