… SARS-CoV-2 … SARS-CoV-2 colocalizes within autophagosomes but not with a lysosomal
marker. Our findings indicate that SARS-CoV-2 can benefit from compromised autophagic flux …

… of the autophagic flux. In particular, ORF3c affects lysosomal acidification, blocking the normal
autophagic … We also observed different effect on autophagy for SARS-CoV-2 and batCoV …

… the effect of the proposed SARS-CoV-2-induced block of the autophagic flux, we co-treated …
if SARS-CoV-2 reduces autophagic flux in vivo, we analyzed lung samples from SARS-CoV-2…

… To dissect whether this accumulation is due to de novo induction of autophagy or rather
caused by a block of autophagic flux, we reexamined the impact of these proteins on …

… -2 genome, particularly in the modulation of macroautophagy/autophagy flux and function
… by which SARS-CoV-2 ORF7a intercepts autophagic flux, evades host autophagy-lysosome …

… inducer Torin1 was used to examine the autophagy flux in the SARS-CoV-2 ORF7a …
that SARS-CoV-2 ORF7a blocked autophagy flux by intervening in autophagosome and …

… SARS-CoV-2 infection in Vero E6 cells also resulted in virus retention inside the cells and
trafficking of virus… where SARS-CoV-2 benefits from compromised autophagic flux and …

… Consistent with this observation, we found that the autophagic flux inducing p62 (SQSTM1)
and SNAP29 gene expression level were down in SARS-CoV-2-positive human samples. …

… In line with these reports, a recent study, using ATG5 wild-type and ATG5 knockout Vero
B4 cells, reported that MERS-CoV infection suppresses autophagy flux by inhibiting the fusion …

… , which may explain the epidemic potential of SARS-CoV-2. Taken together, our results
indicate the unique role of the SARS-CoV-2 ORF3a in suppressing STING-mediated autophagy, …