Autophagy modulation as a potential therapeutic target for diverse diseases

DC Rubinsztein, P Codogno, B Levine - Nature reviews Drug discovery, 2012 - nature.com
… for autophagy inhibition, autophagy upregulation and modulation of the clearance of selective
autophagy … agents that are currently available as potential drugs and chemical probes. …

Autophagy modulation: a target for cancer treatment development

A Duffy, J Le, E Sausville, A Emadi - Cancer chemotherapy and …, 2015 - Springer
… Defects in this process are associated with genomic damage, susceptibility to metabolic
stress, and tumor growth, suggesting a role for autophagy modulation in tumor suppression. …

Autophagy modulation as a target for anticancer drug discovery

X Li, H Xu, Y Liu, N An, S Zhao, J Bao - Acta Pharmacologica Sinica, 2013 - nature.com
… Accumulating data has demonstrated the efficiency of existing autophagy modulating agents
in … strategies may launch a new wave of drug discovery through the targeting of autophagy. …

Recent update and drug target in molecular and pharmacological insights into autophagy modulation in cancer treatment and future progress

MA Rahman, ASM Saikat, MS Rahman, M Islam… - Cells, 2023 - mdpi.com
Autophagy modulation in response to medicines can be pro-death or pro-survival… drug
resistance [18]. Therefore, this review presents the current understanding of autophagy modulation

Targeting autophagy as a strategy for drug discovery and therapeutic modulation

L Gao, CE Jauregui, Y Teng - Future medicinal chemistry, 2017 - Taylor & Francis
… Therefore, the combination of autophagy modulation and molecular targeted therapy is a …
Autophagy modulation as a potential therapeutic target for diverse diseases. Nat. Rev…

Autophagy modulation as a potential targeted cancer therapy: From drug repurposing to new drug development

CJ Lin, YN Tsao, CW Shu - The Kaohsiung Journal of Medical …, 2021 - Wiley Online Library
… This review summarizes current autophagy modulation used as a potential strategy for
targeted cancer therapy. … Thus, autophagy modulation is a potential route for cancer therapy. …

Autophagy is a therapeutic target in anticancer drug resistance

S Chen, SK Rehman, W Zhang, A Wen, L Yao… - … et Biophysica Acta (BBA …, 2010 - Elsevier
… evidence for autophagy's involvement in mediating resistance of cancer cells to anticancer
therapy and suggest that autophagy might be a potential therapeutic target in anticancer drug

Autophagy modulators: mechanistic aspects and drug delivery systems

S Tavakol, M Ashrafizadeh, S Deng, M Azarian… - Biomolecules, 2019 - mdpi.com
Autophagy modulation is considered to be a promising programmed cell death mechanism
to prevent and cure a great number of disorders and diseases. The crucial step in designing …

Autophagy as a modulator and target in prostate cancer

JM Farrow, JC Yang, CP Evans - Nature reviews Urology, 2014 - nature.com
modulation (with added emphasis on alterations occurring within prostate … autophagy, and
the current status of research providing support for the use of adjuvant autophagic modulation

Autophagy modulation for cancer therapy

ZJ Yang, CE Chee, S Huang… - Cancer biology & …, 2011 - Taylor & Francis
… has been shown to enhance anticancer drug-induced cell death, suggesting a … modulate
autophagy for cancer prevention and therapy, and to exploit it as a target for anticancer drug