Axon sprouting in the spinal cord: growth promoting and growth inhibitory mechanisms

JP Kapfhammer - Anatomy and embryology, 1997 - Springer
… In the spinal cord, collateral sprouting is … In the spinal cord of adult animals, axon sprouting
can be observed but is strongly restricted. The factors that determine the amount of sprouting

Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity

IC Maier, ME Schwab - … of the Royal Society B: Biological …, 2006 - royalsocietypublishing.org
spinal cord function and injury, the current experimental therapeutic approaches, the
development of spinal cord … In the developing spinal cord, outgrowing CST axon collaterals of the …

Sprouts from cut corticospinal axons persist in the presence of astrocytic scarring in long-term lesions of the adult rat spinal cord

Y Li, G Raisman - Experimental neurology, 1995 - Elsevier
… after the lesion the main axonal stems of both cut and … of sprouts directed into the centrał,
macrophage-filled area of the lesion. The present experiments indicated that the axon sprouts

Transgenic inhibition of astroglial NF‐κB leads to increased axonal sparing and sprouting following spinal cord injury

R Brambilla, A Hurtado, T Persaud… - Journal of …, 2009 - Wiley Online Library
… increased axonal sparing or sprouting compared to WT, we performed retrograde tract
tracing via bilateral injection of FG caudally to the injury site 8 weeks after spinal cord contusion (…

Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord

Y Li, G Raisman - Journal of Neuroscience, 1994 - Soc Neuroscience
… Schwann cell transplant (SC) gives rise to a multiply branched axonal sprout (arrow). E,
Camera lucida drawing of the sprouting axon from D to show transverse turning (t) and varicose …

Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury

H Lee, RJ McKeon… - Proceedings of the …, 2010 - National Acad Sciences
… regenerative failure after spinal cord injury (SCI… axonal sprouting and functional recovery
in various animal models (4). chABC promotes sprouting in both intact and injured spinal cords (…

The extracellular environment of the CNS: influence on plasticity, sprouting, and axonal regeneration after spinal cord injury

S Quraishe, LH Forbes, MR Andrews - Neural plasticity, 2018 - Wiley Online Library
… the inhibitory glial scar, which actively prevents axonal regeneration. Myelin sheaths and
mature adult … to or prevent plasticity, sprouting, and axonal regeneration after spinal cord injury. …

BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury

M Sasaki, C Radtke, AM Tan, P Zhao… - Journal of …, 2009 - Soc Neuroscience
… promoted CST sprouting into the … axonal sprouting induced by BDNF-hMSC may contribute
to recovery through an enhancement of polysynaptic connections to the caudal spinal cord. …

Differential effect of aging on axon sprouting and regenerative growth in spinal cord injury

A Jaerve, N Schiwy, C Schmitz, HW Mueller - Experimental neurology, 2011 - Elsevier
… The demographics of acute spinal cord injury (SCI) are changing … We investigated axonal
sprouting along with the efficiency of … Axon outgrowth was investigated by immunohistological …

Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury

L Zhou, HD Shine - Journal of neuroscience research, 2003 - Wiley Online Library
… Our results are analogous to reports of increased compensatory axonal sprouting in injured
spinal cord after other types of treatments. For example, cortical injection of the monoclonal …