Evidence for galanin receptors in primary sensory neurones and effect of axotomy and inflammation

ZQ Xu, TJ Shi, M Landry, T Hökfelt - Neuroreport, 1996 - journals.lww.com
… In the present study we demonstrate that the first cloned galanin receptor, GAL-R1, is expressed
in at least 1/5 of all DRG neurones and that these neurones also express CGRP mRNA. …

Expression and regulation of galanin-R2 receptors in rat primary sensory neurons: effect of axotomy and inflammation

TJS Shi, X Zhang, K Holmberg, ZQD Xu, T Hökfelt - Neuroscience letters, 1997 - Elsevier
… Using in situ hybridization, we studied galanin-R2 receptor (… tissue inflammation and sciatic
nerve transection (axotomy). … profiles after peripheral tissue inflammation with a peak at 3 …

Central and peripheral expression of galanin in response to inflammation

RR Ji, X Zhang, Q Zhang, Å Dagerlind, S Nilsson… - Neuroscience, 1995 - Elsevier
… and their processes, and also that galanin released from primary afferents reacts mainly
with post-junctional galanin receptors. Since axotomy produces a marked plasticity in neuro…

A new gal in town: a systematic review of the role of galanin and its receptors in experimental pain

D Fonseca-Rodrigues, A Almeida, F Pinto-Ribeiro - Cells, 2022 - mdpi.com
… Additionally, after axotomy of the sciatic nerve, blocking galanin action by the administration
… anti-inflammatory role for this receptor. After inflammation or nerve injury, galanin receptors

Regulation of expression of galanin and galanin receptors in dorsal root ganglia and spinal cord after axotomy and inflammation.

XU Zhang, ZO Xu, TJ Shi, M Landry… - Annals of the New …, 1998 - europepmc.org
galanin-R2 receptor mRNA levels increase. The present results show that galanin and galanin
receptors … local dorsal horn neurons and are regulated by nerve injury and inflammation. …

Galanin in Somatosensory Function a

Z WIESENFELD‐HALLIN… - Annals of the New York …, 1998 - Wiley Online Library
… the galanin R1 receptor found in normal DRG cells in rat was transiently downregulated during
inflammation, 10 whereas the R2 galanin receptor … that following axotomy galanin may be …

Differential distribution and regulation of galanin receptors-1 and-2 in the rat lumbar spinal cord

P Brumovsky, F Mennicken, D O'donnell, T Hökfelt - Brain research, 2006 - Elsevier
… The expression of the galanin receptor-1 and -2 (Gal 1 and … unilateral axotomy of the sciatic
nerve or unilateral inflammation … In this study, crushing or axotomy of the facial nerve induced …

Inflammation-and axotomy-induced changes in galanin-like immunoreactive (GAL-LI) nerve structures in the porcine descending colon

S Gonkowski, P Burliński, C Skobowiat… - Acta Veterinaria …, 2010 - akjournals.com
… This study reports on changes caused by chemically driven inflammation and axotomy in
galanin-… Both colitis and axotomy caused an increase in GALlike immunoreactivity, which was …

The participation of galanin in pain processing at the spinal level

HX Liu, T Hökfelt - Trends in pharmacological sciences, 2002 - cell.com
… is regulated by nerve injury and peripheral inflammation. The functional significance of such
… distinctly changed by axotomy because GAL1 receptor and GAL2 receptor mRNA levels are …

The role of galanin as a multi-functional neuropeptide in the nervous system

D Wynick, SWN Thompson, SB McMahon - Current opinion in …, 2001 - Elsevier
… After axotomy, galanin mRNA and peptide are abundantly expressed in 40–50% of all DRG
… a dual role for galanin as a central, spinal mediator of inflammatory pain hypersensitivity and …