… Herein, as a continuation of our research on the development of quinoline-based antimalarial
agents, we report the synthesis of a series of 4-pyridylvinylquinoline-triazole conjugates …

… To prevent the selection of resistant parasites, WHO has recommended the combination
of artemisinins with traditional antimalarial drugs such as lumefantrine, amodiaquine and …

… We describe the synthesis and antimalarial activities of 1H-1,2,3-triazole tethered 7-chloroquinoline-isatin
hybrids. Activity against cultured parasites was dependent on the C-5 …

… Concurrently, using both ART-alkyne and azide optimized probes we were able to identify
59 P. falciparum proteins with high confidence that were specifically alkylated by ART pointing …

… antimalarial drugs has been observed as a consequence of genetic mutations and is a serious
setback to antimalarial … terminal alkyne 11 and the organic azide 9 in a convergent route. …

… azide–alkyne cycloaddition, an alternative metal-free pathway has never been reported for
the synthesis of antimalarial … been used before to synthesize antimalarial drug compounds. …

… (ART) class of antimalarial drugs, the most important antimalarial drug class in use today, …
, peptide linkers of maximum three carbons were used for our alkyne and azide probes. …

… continuing need for new antimalarial drugs that are effective, … and synthesis of antimalarial
agents from microbial metabolites … Moreover, as the discovery of the antimicrobial alkyne-…

… drug resistance. ACTs use ART or its derivatives together with one or more other antimalarial
drugs … hand, we linked the alkyne-tagged analogues to biotin azide through click chemistry (…

… resistance associated with chloroquine analogues. … designed and synthesized as novel
antimalarial agents using the Cu(I)-… -4-amine alkyne precursor and the azides of ethyl and propyl …