A robust platform for chemical genomics in bacterial systems
… chemical probes. We have developed a robust and sensitive platform for chemical-genomic
investigations in bacteria. … We found that chemical-genomic profiles were highly sensitive to …
investigations in bacteria. … We found that chemical-genomic profiles were highly sensitive to …
The impact of bacterial genomics on natural product research
HB Bode, R Müller - Angewandte Chemie International Edition, 2005 - Wiley Online Library
… relative to related bacterial systems. One forseeable problem with fungal systems is the lack
of … Nevertheless, there is enormous potential in fungal systems, and most of the advantages …
of … Nevertheless, there is enormous potential in fungal systems, and most of the advantages …
Merging chemical ecology with bacterial genome mining for secondary metabolite discovery
MI Vizcaino, X Guo, JM Crawford - Journal of Industrial …, 2014 - academic.oup.com
… By examining bacterial … bacteria with experimentally linked biosynthetic gene clusters as
illustrative examples of the synergy between chemical ecology and bacterial genome mining in …
illustrative examples of the synergy between chemical ecology and bacterial genome mining in …
Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting
… chemical probes of biological systems … this chemical genomic approach, we demonstrate
that the targets of well-known antibiotics can be identified as high copy suppressors of chemical …
that the targets of well-known antibiotics can be identified as high copy suppressors of chemical …
Microbial genomics and the periodic table
LP Wackett, AG Dodge, LBM Ellis - Applied and environmental …, 2004 - Am Soc Microbiol
… the genomes of bacteria and archaea, suggesting that magnesium ion transport is important
throughout prokaryotic systems (… Ca 2+ is much less abundant in bacteria than Mg 2+ , being …
throughout prokaryotic systems (… Ca 2+ is much less abundant in bacteria than Mg 2+ , being …
From genomics to chemical genomics: new developments in KEGG
M Kanehisa, S Goto, M Hattori… - Nucleic acids …, 2006 - academic.oup.com
… on the genomic space of possible genes and proteins that make up the … system, the new
chemical genomics initiatives will give us a glimpse of the chemical space of possible chemical …
chemical genomics initiatives will give us a glimpse of the chemical space of possible chemical …
Synergizing the potential of bacterial genomics and metabolomics to find novel antibiotics
… approach based on bacterial genomics and metabolomics. Novel … in publicly available bacterial
genome data has shown that … (BGC) encoded in the genome of each microbial strain and …
genome data has shown that … (BGC) encoded in the genome of each microbial strain and …
Comparative genomic reconstruction of transcriptional regulatory networks in bacteria
DA Rodionov - Chemical reviews, 2007 - ACS Publications
… The Genome Explorer software for bacterial genome analysis provides tools for both genome-…
To reconstruct the l-rhamnose utilization system in bacteria, we used a subsystem-based …
To reconstruct the l-rhamnose utilization system in bacteria, we used a subsystem-based …
Chemical genomics reveals mechanistic hypotheses for uncharacterized bioactive molecules in bacteria
… chemical–genetic interactions can provide readily testable hypotheses into the mechanistic
underpinnings of bioactive chemical matter in bacteria … of chemical genomics approaches in …
underpinnings of bioactive chemical matter in bacteria … of chemical genomics approaches in …
Model systems in drug discovery: chemical genetics meets genomics
PM Carroll, B Dougherty, P Ross-Macdonald… - Pharmacology & …, 2003 - Elsevier
… The sequencing of not only the human genome but also those of the various pathogenic
bacteria, … of genomics on the study of bacteria and the development of therapies to fight bacterial …
bacteria, … of genomics on the study of bacteria and the development of therapies to fight bacterial …