… chemical probes. We have developed a robust and sensitive platform for chemical-genomic
investigations in bacteria. … We found that chemical-genomic profiles were highly sensitive to …

… relative to related bacterial systems. One forseeable problem with fungal systems is the lack
of … Nevertheless, there is enormous potential in fungal systems, and most of the advantages …

… By examining bacterial … bacteria with experimentally linked biosynthetic gene clusters as
illustrative examples of the synergy between chemical ecology and bacterial genome mining in …

… chemical probes of biological systems … this chemical genomic approach, we demonstrate
that the targets of well-known antibiotics can be identified as high copy suppressors of chemical …

… the genomes of bacteria and archaea, suggesting that magnesium ion transport is important
throughout prokaryotic systems (… Ca 2+ is much less abundant in bacteria than Mg 2+ , being …

… on the genomic space of possible genes and proteins that make up the … system, the new
chemical genomics initiatives will give us a glimpse of the chemical space of possible chemical …

… approach based on bacterial genomics and metabolomics. Novel … in publicly available bacterial
genome data has shown that … (BGC) encoded in the genome of each microbial strain and …

… The Genome Explorer software for bacterial genome analysis provides tools for both genome-…
To reconstruct the l-rhamnose utilization system in bacteria, we used a subsystem-based …

… chemical–genetic interactions can provide readily testable hypotheses into the mechanistic
underpinnings of bioactive chemical matter in bacteria … of chemical genomics approaches in …

… The sequencing of not only the human genome but also those of the various pathogenic
bacteria, … of genomics on the study of bacteria and the development of therapies to fight bacterial …