… on BAFF or APRIL and thus the response to blockade. … BAFF blockade in a murine model
of SLE. Our results show that although both BAFF-R–Ig and TACI-Ig prevented the onset of SLE …

… There was a significant increase in the frequency of CD27 + memory cells, consistent with
our findings in mice that memory B cells are resistant to BAFF blockade. There was a modest …

… BAFF blockade as an effective therapy for SLE warrants an analysis of its mechanism of action
in diverse SLE … of action of BAFF blockade in 2 different models of murine lupus (for review…

… role for BAFF in murine SLE, evidence in support for a contributory role for APRIL in … or
genetic depletion of BAFF in murine SLE. Comparing human SLE trials to murine SLE trials is akin …

… murine SLE, with the goal of informing the interpretation of human clinical trials of BAFF
blockade … of selective BAFF blocking agents, we will only consider the anti-BAFF monoclonal …

… We have shown in both strains that BAFF inhibition effectively delays the onset of SLE … It is
unknown whether BAFF inhibition alters the quality of the autoantibody response in SLE mice …

… disease similar to SLE in humans. Together with the observation that BAFF blockade
decreased symptoms of SLE in mouse models, 30 these findings promoted BAFF as a therapeutic …

… to evaluate, in a mouse model and in SLE patients, whether BAFF neutralization has an …
mouse model and in a cohort of SLE patients. Mice were treated with a blocking anti-BAFF …

… murine models of SLE. A constitutive overproduction of BAFF in some mice transgenic for the
human or murine … biological activity of soluble BAFF by blocking its interaction with BAFF-R, …

… BAFF blockade can be used to prevent or treat antiphospholipid syndrome in a mouse … BAFF
blockade did not prevent the development of aCL, and there was only a modest delay in the …