… We propose that the compromised epithelial barrier function in asthma is not secondary …
allergic asthma. The first direct link between compromised epithelial barrier function and allergy …

… barrier affects innate and adaptive immunity. We discuss why defective … barrier function
might be linked to T H 2 polarization in asthmatic patients and propose a rheostat model of barrier …

… barrier properties and how dysregulation of these homeostatic mechanisms can contribute
to disease pathologies such as asthma. … shown to improve epithelial barrier function in air–…

… a mediator of TJ disruption in asthma, our in vitro data suggest an IL-13–independent effect,
as baseline barrier function was lower in cultures from asthmatic subjects. In support of this, …

… is hampered is through the disruption of the epithelial barrier function. Allergens, pathogens,
and … to the airway vessels in allergic versus control mice. Airway diseases such as AR, CRS, …

… the regulatory function of the airway epithelial barrier has recently been … asthma. Here we
discuss the mechanism by which airway barrier function is disrupted in association with allergic …

… Several findings strongly indicate that in asthma patients the barrier function is impaired by
epithelial disruption. For example, endobronchial biopsies revealed a fragile or even injured …

… cells controls the tissue microenvironment and barrier homeostasis. This is achieved by …
In asthmatic patients abnormalities in many aspects of epithelial barrier function have been …

… ), which is able to increase alveolar barrier functions in vitro 227, has also been … asthmatic
patients with reduced physical barrier functions. Another promising strategy to reduce asthma …

… Conversely, neutralization of IL-22 during allergen challenge increased inflammation,
consistent with the potential of IL-22 to enforce mucosal barrier function, and reduce the …