… cancer worldwide, the development of Basal cell carcinoma (BCC… Thus the discovery of this
central tumor-promoting signalling … development of a completely novel therapeutic approach. …

… cancer-initiating cell in BCCs with its importance for pathogenesis and further development
of targeted therapies is … follicular bulge stem cells or long-term resident progenitor cells of the …

… Due to recent advances, therapeutic strategies based on the precise molecular mechanisms
of basal cell carcinoma are emerging. Target therapies and biomarkers are also discussed. …

… Targeted therapy has shown promise in the treatment of … basal cell carcinoma (therapy
directed against the hedgehog pathway) and cutaneous squamous cell carcinoma (therapy …

… ) and SMO genes cause tumor formation through constitutive … the nevoid basal cell carcinoma
syndrome and other tumors. … basal cell carcinoma and review potential targeted therapies. …

… The search terms BCC, metastatic basal-cell carcinoma, smoothened inhibitor, Hedgehog
… , and targeted therapy were used for this search. Additionally, abstracts from national cancer …

… lead to advanced basal cell carcinoma shrinkage that can … basal cell carcinomas. We also
highlight current gaps in knowledge regarding the use and side effects of this targeted therapy. …

… Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs …
, if they do, these advanced basal cell carcinoma become amenable to treatment by inhibiting …

… Although these systemic targeted therapies can lead to notable tumor shrinkage and even …
are likely to respond to these targeted treatments. Various intermittent and maintenance drug …

… Basal cell carcinoma (BCC) and medulloblastoma are two well-… therapeutic options available
for the treatment of locally advanced and metastatic BCC, and the new targeted therapies …